Basic Medicine, Molecular and Cellular Biology

Molecular Pharmacology

To Explore the Molecular Targets for the New Drug Therapy, Especially in Cardiovascular Diseases

Medical Sciences Course

  • Master / Doctoral Degree

Faculty

YANAI, KazuhikoYANAI, Kazuhiko
YANAI, Kazuhiko*

Professor, M.D. Ph.D.

*Concurrent Position

Research Theme

  • Regulation of intracellular signaling and dynamics of G protein-coupled receptor (GPCR) by GPCR-interacting proteins
  • Mitochondrial quality control and drug-induced cardiotoxicity
  • Physiological roles of primary cilium and its regulatory mechanisms
Research Keywords:

mitochondrial disease, GPCR-mediated signal transduction, primary ciliary dyskinesia

Technical Keywords:

autophagy, molecular biology, cellular biology, reactive oxygen species

Laboratory Introduction

We have developed various novel cardiovascular and neurological drugs including Ca2+ channel blockers, nicorandil, and new cardiotonic agents. Recently we have investigated molecular mechanisms of GPCR-mediated signal transduction and primary cilium, a new concept of signal acceptor, using state-of-the-art techniques. We have also investigated a new concept relating with the quality control of mitochondria. Thus, we have a point of view to develop new drugs to treat intractable diseases, including mitochondrial disease. You can also catch both pharmacology and molecular basis of pharmacotherapeutics in our laboratory. Please join us for the future area to develop new drugs and diagnostic maneuvers.

Figure 1. Regulation of functions mediated through GPCR and primary cilium

Figure 1. Regulation of functions mediated through GPCR and primary cilium

Figure 2. Effect of cardiotoxic agents on mitochondrial quality control

Figure 2. Effect of cardiotoxic agents on mitochondrial quality control

Recent Publications

  • Suzuki T., et al.? Mitochonic acid MA-5 binds to mitochondria and ameliorates renal tubular and cardiac myocyte damages. J Am Soc Nephrol. doi: 10.1681/ASN.2015060623
  • Murakami M, et al.? Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity. Biochem Biophys Res Commun., 458, 584-589 (2015).
  • Sato T, et al. Evaluation of bystander cell killing effects in suicide gene therapy of cancer: Engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis. Methods Mol Biol., 1317:55-67(2015).
  • Suzuki T, et al.? Mitochonic acid 5 (MA-5), a derivative of the plant hormone indole-3-acetic acid, improves survival of fibroblasts from patients with mitochondrial diseases. Tohoku J Exp Med. 236, 225-232 (2015).
  • Sato T., et al.? The Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis Offers Efficient Bystander Cell Killing for Suicide Gene Therapy of Cancer. PLOS ONE 8, e78711 (2013).
  • Katsushima Y., et al.?Interaction of PICK1 with C-Terminus of Growth Hormone?Releasing Hormone Receptor (GHRHR) Modulates Trafficking and Signal Transduction of Human GHRHR. J. Pharmacol. Sci., 122, 193-204 (2013).