Basic Medicine, Physiology, Molecular and Cellular Biology

Medicine and Science in Sports and Exercise

Multidisciplinary Approach to Health and Sports Science Covering Molecular Biology to Epidemiology

  • Master / Doctoral Degree

Faculty

NAGATOMI, RyoichiNAGATOMI, Ryoichi
NAGATOMI, Ryoichi

Professor, M.D. Ph.D.

*Concurrent Position

Research Theme

  • Cellular basis of skeletal muscle adaption focusing on satellite cells
  • Investigation of risk factors for sarcopenia diabetes, cardiovascular diseases and depression
  • Investigation and prevention of chronic sports injuries
Research Keywords:

satellite cells, hypoxic pathway, sarcopenia, physical activity, microbiome

Technical Keywords:

wearable sensors, motion analysis, metagenomic analysis, cohort studies

Laboratory Introduction

Professor Ryoichi Nagatomi, vice president of the Japanese Society of Physical Fitness and Sports Medicine, a Fellow of European College of Sports Science (ECSS) and the past president of International Society of Exercise and Immunology, has been making significant contributions to exercise and sports science, using multidisciplinary approach covering molecular and cellular biology, immunology, cardiovascular physiology, biomechanics, and epidemiology and bioinformatics. He is targeting a wide range of research questions involving physical activity/inactivity, exercise and sports, cardiovascular diseases and sarcopenia. Current topics are 1) role of protein disposal systems in skeletal muscles, 2) contribution of hypoxic responsive pathway on exercise capacity, 3) cross talk of skeletal muscle and gut microbiome, 4) investigation of risk factors for diabetes, cardiovascular diseases and sarcopenia, 5) investigation of risk factors for chronic sports injury of children and youths, 6) biomechanical approach for sports injury prevention utilizing wearable sensors.
Students from abroad are most welcome. Students from China, Egypt, Hungary, Korea, Indonesia, Mexico, Russia, and Finland had previously joined our lab. Full English conversation in lab meetings is guaranteed.

Figure 1. Multidisciplinary approach to health and sports science

Figure 1. Multidisciplinary approach to health and sports science

Figure 2. Investigation of skeletal muscle adaptation from molecules to human body and population

Figure 2. Investigation of skeletal muscle adaptation from molecules to human body and population

Recent Publications

  • 1.Nunomiya A, et al. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta physiologica 2016.
  • 2.Shin J, et al. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skelet Muscle 6: 5, 2016.
  • 3.Huang C, et al. High serum adiponectin levels predict incident falls among middle-aged and older adults: a prospective cohort study. Age Ageing 45: 366-371, 2016.
  • 4.Sato K et al. Improving Walking, Muscle Strength, and Balance in the Elderly with an Exergame Using Kinect: A Randomized Controlled Trial. Games Health J 4: 161-167, 2015.
  • 5.Momma H, et al. Lower serum endogenous secretory receptor for advanced glycation end product level as a risk factor of metabolic syndrome among Japanese adult men: a 2-year longitudinal study. J Clin Endocrinol Metab 99: 587-593, 2014.