Basic Medicine, Molecular and Cellular Biology, Immunology

Medical Microbiology, Mycology and Immunology

To Challenge Mechanism of Immune System for Protecting Host from Microbial Infection: Development of Novel Vaccines and Stealth Nanoparticles

Health Sciences Course

  • Master / Doctoral Degree

Faculty

KAWAKAMI, KazuyoshiKAWAKAMI, Kazuyoshi
KAWAKAMI, Kazuyoshi

Professor, M.D. Ph.D.

*Concurrent Position

Research Theme

  • Clarification of host immune mechanism against microbial infection
  • Development of novel vaccines
  • Development of stealth nanoparticles for novel therapy of malignant diseases
Research Keywords:

infection and immunity, immune memory, fungus, vaccine, nanoparticle

Technical Keywords:

experiment with microbial infection, animal experiment, immunological analysis, molecular biological analysis, pathological analysis

Laboratory Introduction

In our laboratory, we aim to clarify the immune mechanism against infection with microbial pathogens such as fungi and bacteria from the perspectives of innate immunity, acquired immunity and immune memory. We also attempt to extend the results obtained from these studies to development of novel vaccines and that of stealth nanoparticles for novel anti-cancer therapies which make it possible to bring them more efficiently to cancer tissues without trapped by reticuloendothelial system and without stimulating immune response.

Figure 1. Possible relationship of microbial infection with various diseases

Figure 1. Possible relationship of microbial infection with various diseases

Figure 2. Intracellular signaling in TLR9-mediated activation of macrophages and dendritic cells by <i>Cryptococcus neoformans</i>

Figure 2. Intracellular signaling in TLR9-mediated activation of macrophages and dendritic cells by <i>Cryptococcus neoformans</i>

Recent Publications

  • Yamamoto H, et al. Defect of CARD9 leads to impaired accumulation of IFN-γ-producing memory-phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans, Infect Immun 82: 1606-1615, 2014
  • Miyasaka T, et al. Dectin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine. PLoS One 8:e78611, 2013
  • Togashi T, et al. Continuous hydrothermal synthesis of 3,4-dihydroxyhydrocinnamic acid-modified magnetite nanoparticles with stealth-functionality against immunological response. J Materials Chemi 22: 9041-9045, 2012
  • Kinjo Y, et al. Invariant NKT cells recognize glycolipids from pathogenic gram-positive bacteria. Nat Immunol 12: 966-974, 2011
  • Saijo S, et al. Dectin-2 is crucial for the defense against Candida albicans in mice by recognizing alpha-mannans and inducing Th17 differentiation. Immunity 32: 681-691, 2010