Basic Medicine, Molecular and Cellular Biology
Endocrinology and Applied Medical Science
To Clarify Pathophysiology via the Research in Biologically Active Peptides, and to Aim at the Translational Research in Laboratory Medicine
Health Sciences Course
- Master / Doctoral Degree
- TAKAHASHI, Kazuhiro
Professor, M.D. Ph.D.
ktaka-md*med.tohoku.ac.jp (Please convert "*" into "@".)
- Studies on neuropeptides and cardiovascular peptides in the pathophysiology of cardiovascular diseases, and neuroendocrine diseases
- (Patho)physiology of prorenin receptor in cancer, erythropoiesis and sleep apnea syndrome
- Translational research in laboratory medicine
neuropeptide, prorenin receptor, physiological function, neuroendocrinology, cardiovascular endocrinology
cell culture, molecular biology, immunohistochemistry, western blot analysis, ELISA
The Department of Endocrinology & Applied Medical Science is studying neuropeptides and cardiovascular peptides in order to clarify (patho) physiological roles of biologically active peptides in normal conditions and various diseases.
Biologically active peptides are produced and secreted not only by endocrine cells and neurons, but also by cardiomyocytes (atrial natriuretic peptide and B-type natriuretic peptide), vascular endothelial cells (endothelins), immune cells (ACTH and corticotropin-releasing hormone), adipocytes (leptin and resistin), etc. We aim at the translational research in the fields of neuroendocrinology and cardiovascular endocrinology to develop novel test methods in laboratory medicine and treatments for various diseases, such as the metabolic syndrome, hypertension, diabetes mellitus, chronic kidney diseases, and malignant neoplasm.
In these recent years, we have focused on the research in prorenin receptor, receptor for renin precursor. In particular, we have been studying pathophysiological roles of prorenin receptor in cancers, relationship between erythropoiesis and prorenin receptor, and plasma levels of soluble prorenin receptor in patients with obstructive sleep apnea syndrome. Studies on obstructive sleep apnea syndrome have been done in co-operation with Division of Behavioral Sleep Medicine, Iwate Medical University School of Medicine, Morioka, Japan (directed by Prof. Shigeru Sakurai).
Figure 1. Immunohistochemistory of prorenin receptor in invasive breast cancer
Figure 2. Correlation between plasma soluble prorenin receptor and apnea hypopnea index
- Ohba K, et al. Expression of (pro)renin receptor in breast cancers and its effect on cancer cell proliferation. Biomed Res (Tokyo), 35:117-126; 2014
- Nishijima T, Tajima K, Takahashi K, Sakurai S. Elevated plasma levels of soluble (pro)renin receptor in patients with obstructive sleep apnea syndrome: Association with polysomnographic parameters. Peptides, 56:14-21; 2014
- Yamamoto H, et al. Increased expression of (pro)renin receptor in aldosterone-producing adenomas. Peptides, 49:68-73; 2013
- Kaneko K, et al. Expression of (pro)renin receptor in human erythroid cell lines and its increased protein accumulation by interferon-γ. Peptides, 37:285-289; 2012
- Takahashi K, Totsune K. Urotensin peptides, p. 1437-1442. In Kastin AJ (ed), Handbook of Biologically Active Peptides, Second Edition. Elsevier, Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo 2013