Basic Medicine, Physiology

Laboratory Animal Medicine

Development of Prevention, Diagnosis, and Treatment Methods for Various Diseases by Understanding Pathogenic Mechanisms through Establishment of Innovative Animal Models

Medical Sciences Course

  • Master / Doctoral Degree

Faculty

MIYOSHI, IchiroMIYOSHI, Ichiro
MIYOSHI, Ichiro

Professor, D.V.M. Ph.D. DJCLAM

  • TEL

    +81-22-717-8174, 8175

  • Mail

    ichirom*med.tohoku.ac.jp (Please convert "*" into "@".)

*Concurrent Position

Research Theme

  • Identification and analysis of responsible genes for refractory diseases by reverse and forward genetics
  • Development of new genetically modified animal by developmental engineering technology
  • Development of new genetically modified animal to investigate the pathophysiological roles of cell surface glycoconjugates
Research Keywords:

comparative and experimental medicine, genetically engineered animal, disease-associated gene, developmental engineering, cell-surface glycoconjugates

Technical Keywords:

genetically engineered animal, developmental engineering, genome editing, animal experimentation

Laboratory Introduction

The institute for Animal experimentation is a facility for rearing laboratory animals with about 30 care takers. We are now maintaining about 30,000 laboratory animals including mice, rats, rabbits, dogs, pigs and monkeys. In our research laboratory, we are investigating comparative and experimental medicine and educating graduate students in the field of laboratory animal science and medicine. We perform research using laboratory animals to try to find out human characteristics. We are studying the causes and pathology of hereditary diseases using spontaneous and transgenic animal models for human diseases such as rats with diabetes mellitus, mice with congenital cataracts, mice with Menkes disease and rats with Wilson's disease. In addition, one of the recent topics in our laboratory is pathophysiological role of glycosphingolipids (GSLs). We found that aberrant expression of a GSLs synthase dramatically promotes proliferation of intestinal epithelial cells. It is likely to be a model of initial stage of colon cancer. Other models reveal various changes in their phenotypes, including metabolic disorder, dysontogenesis and cancer. We are exploring molecular events underlying these phenotypic change.

Figure 1. Specific pathogen-free (SPF) animal room of the facility

Figure 1. Specific pathogen-free (SPF) animal room of the facility

Figure 2. Invasive serous carcinoma of the ovary of mOGP-Tag transgenic mice

Figure 2. Invasive serous carcinoma of the ovary of mOGP-Tag transgenic mice

Recent Publications

  • Sherman-Baust CA, et al. A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development. J Pathol. 233(3):228-237, 2014
  • Taguchi K, et al. Colony-stimulating factor-1 signaling suppresses renal crystal formation. J Am Soc Nephrol. 25(8):1680-1697, 2014
  • Kitamura H, et al. Beneficial effects of Brazilian propolis on type 2 diabetes in ob/ob mice: Possible involvement of immune cells in mesenteric adipose tissue. Adipocyte. 2(4):227-36, 2013
  • Kitamura H, et al. Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation. FASEB J. 27(12):4940-4953, 2013
  • Okamura T, et al. Phenotypic Characterization of LEA Rat: A New Rat Model of Nonobese Type 2 Diabetes. J Diabetes Res. 2013:986462, 2013