Basic Medicine, Molecular and Cellular Biology


Aging and Metabolic Regulation

Medical Sciences Course

  • Master / Doctoral Degree


*Concurrent Position

Research Theme

  • Functional genomics of lipoprotein receptors
  • Functional genomics of acyl-CoA synthetases
  • Wnts and metabolic regulation
Research Keywords:

cholesterol, atherosclerosis, aging, wnt, obesity

Technical Keywords:

protein analysis, gene analysis, biochemical analysis

Laboratory Introduction

Studies with yeast, C. elegance, mouse and rhesus monkeys have shown that calorie restriction expands their life spans. In human, excess food intake causes obesity and subsequently leads to metabolic syndrome that is characterized by decreased glucose tolerance. In our laboratory, we have identified and characterized lipoprotein receptors that play a key role in the plasma clearance of lipoproteins. We also identified and characterized several acyl-CoA synthetases that catalyze the initial reaction of fatty acid metabolism. In addition to these molecules in the lipid metabolism, we are studying on the metabolic regulation mediated by wnt proteins.

Recent Publications

  • Sakakibara I, et al. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Cell Metab. 2009 Feb;9(2):191-202. doi: 10.1016/j.cmet.2008.12.008.