Basic Medicine, Molecular and Cellular Biology

Clinical Biology and Hormonal Regulation

Development of the Treatment of Chronic Renal Failure and Mitochondria Medicine

Medical Sciences Course

  • Master / Doctoral Degree

Faculty

ABE, TakaakiABE, Takaaki
ABE, Takaaki

Professor, M.D. Ph.D.

*Concurrent Position

Research Theme

  • Mitochondrial Medicine
  • CKD and gut micorbiota
  • Transporter Medicine
Research Keywords:

transporter, gut microbiota, tRNA, mitochondrial diseases, anti-fibrosis

Technical Keywords:

transporter, mitochondria, flux analyzser, tRNA, 1-methyladenosine

Laboratory Introduction

Takaaki ABE studied and isolated various uremic solute transporters (e.g. SLCO4C1) and their pathophysiological roles in chronic kidney disease (CKD) and now he is an editorial board member of the American Journal of Physiology (Renal Physiology).
He found that various uremic toxins are generated in the gut and ClC-2 chloride channel activator lubiprostone, clinical used as a laxative, ameliorates the progression of CKD and the accumulation of uremic toxins by improving the gut microbiota and?intestinal environment.
He also reported that have reported that indole acetic acid found in CKD patients increased?erythropoietin production and synthesized its analog mitochonic acid MA-5 increased cellular ATP and rescued fibroblasts from?various mitochondrial disease patients such as Leigh, MELAS, LHON, Kearns-Sayre syndrome (Suzuki T. et al. Tohoku J. Exp. Med. 2015). He also found that MA-5 is also effective in the mitochondrial DNA defect disease model “Mitomice” resucuing cardimyocyte and renal tubular respiration. MA-5 could be novel therapeutic drugs for the treatment of mitochondrial diseases that exerts its?effect in a novel manner different from anti-oxidant therapy (Suzuki T. JANS 2015).

Figure 1. Development of drugs for mitochondrial diseases

Figure 1. Development of drugs for mitochondrial diseases

Figure 2. Alteration of gut microbiota modulates uremic toxins

Figure 2. Alteration of gut microbiota modulates uremic toxins

Recent Publications

  • Suzuki T., Yamaguchi H., Kikusato M., Hashizume O., Nagatoishi S., Matsuo A., Sato T., Kudo T., Matsuhashi T., MurayamaK., Ohba Y., Watanabe S., Kanno S.-I., Minaki D., Saigusa D., Shinbo H., Mori N., Yuri A., Yokoro M., Mishima E., Shima H., Akiyama Y., Takeuchi Y., Kikuchi K., Toyohara T., Suzuki C., Ichimura T., Anzai J., Kohzuki M., Mano N., Kure S., Yanagisawa T., Tomioka Y., Tohyomizu M., Tsumoto K., Kazuto Nakata K., Bonventre J.V., Ito S., Osaka H., Hayashi K. and Abe T. Mitochonic acid MA-5 binds to mitochondria and ameliorates renal tubular and cardiac myocyte damages. J Am Soc Nephrol. in press
  • Suzuki T., Yamaguchi H., Kikusato M., Matsuhashi T., Matsuo A., Sato T., Oba Y., Watanabe S., Minaki D., Saigusa D., Shimbo H., Mori N., Mishima E., Shima H., Akiyama Y., Takeuchi Y., Yuri A., Kikuchi K., Toyohara T., Suzuki C., Kohzuki M., Anzai J., Mano N., Kure S., Yanagisawa T., Tomioka Y., Toyomizu M., Ito S., Osaka H., Hayashi K. and Abe T. Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases.Tohoku J Exp Med. 236: 225-232, 2015
  • Mishima E., Fukuda S., Shima H., Hirayama A., Akiyama Y., Takeuchi Y., Fukuda N.N., Suzuki T., Suzuki C., Yuri A., Kikuchi K., Tomioka Y., Ito S., Soga T. and Abe T.Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD. J Am Soc Nephrol. 26: 1787-94, 2015
  • Takeuchi Y. Mishima E., Shima H., Akiyama Y., Suzuki C., Suzuki T., Kobayashi T., Suzuki Y., Nakayama T., Takeshima Y., Vazquez,N., Ito S., Gammba G. and Abe T.Exonic Mutations in the SLC12A3 Gene Cause Exon Skipping and Premature Termination in Gitelman’s Syndrome. J. Am. Soc. Nephrol. 26: 271-279, 2015
  • Toyohara T., Suzuki T., Akiyama Y., Takeuchi Y., Mishima E., Kikuchi K., Suzuki C., Tanemoto M., Ito S., Nagao S., Soga T. and ABE T. Metabolomic Profiling of the ADPKD rat model. Clin. Exp. Nephrol. 15: 676-687, 2011