Basic Medicine, Oncology

Oncology, Pharmacy Practice and Sciences

To Provide Advanced Personalized Medicine

Medical Sciences Course

  • Doctoral Degree

Faculty

TOMIOKA, YoshihisaTOMIOKA, Yoshihisa
TOMIOKA, Yoshihisa

Professor, Ph.D.

*Concurrent Position

Research Theme

  • Proteomics and metabolomics for the personalized pharmacotherapy
Research Keywords:

metabolomics, LC/MS/MS, personalized medicine

Technical Keywords:

mass spectrometry, chromatography, molecular biology, cell biology

Laboratory Introduction

The medical professional is strongly urged to provide safe, trust-worthy and high level medical care on the patients. The field of medicine is getting more advanced with increasing complexity. The aim of our laboratory is to create a training and education program for medical professionals with the ability to guide advanced personalized medicine using metabolome-based individual information.

Figure 1. Inter-individual difference of chromatograms (LC/MS) acquired from urine samples

Figure 1. Inter-individual difference of chromatograms (LC/MS) acquired from urine samples

Figure 2. Prediction and discovery of new biomarker candidate

Figure 2. Prediction and discovery of new biomarker candidate

Recent Publications

  • Tsuji M., et al. A validated quantitative liquid chromatography-tandem quadrupole mass spectrometry method for monitoring isotopologues to evaluate global modified cytosine ratios in genomic DNA.J Chromatogr B Analyt Technol Biomed Life Sci. 953-954:38-47, 2014
  • Abe T., et al. SLC10A4 is a protease-activated transporter that transports bile acids. J Biochem. 154(1):93-101, 2013
  • Saigusa D., et al. Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry. Anal Bioanal Chem. 403(7):1897-905, 2012
  • Tomioka Y., et al. Education for six-years graduate school of pharmaceutical sciences: a case of Tohoku University.Yakugaku Zasshi. 131(6):933-938, 2011
  • Saigusa D., et al. Simultaneous determination of guanidinosuccinic acid and guanidinoacetic acid in urine using high performance liquid chromatography/tandem mass spectrometry. Anal Chim Acta. 677(2):169-75, 2010