Basic Medicine, Molecular and Cellular Biology
Investigation into the Exacerbation of Allergy by Environmental Factors, and Promotion of Personalized Medicine by Pharmacogenomics
Medical Sciences Course
- Doctoral Degree
- HIRASAWA, Noriyasu
hirasawa*m.tohoku.ac.jp (Please convert "*" into "@".)
- Pathophysiological analysis of allergy/metal allergy
- Development of novel anti-allergic drugs
- Pharmacogenomics for personalized medicine
allergic dermatitis, metal allergy, anti-allergic drugs, personalized medicine, estimation of pharmacokinetics
TSLP-producing cell, quantitation of metal ions, pharmacogenomics, CYP variants
1. Chemicals in environment affect immune responses and worse allergic diseases.
Metal allergies are easily and frequently induced by putting on accessories containing metals and implanting biomedical devices. Our objectives are to clarify the molecular mechanisms by which environmental chemicals and metal ions exacerbate allergic dermatitis and to develop novel anti-allergic drugs.
2. The responsiveness of drugs is varied one by one. The most of variation between individuals is caused mainly by genetic variation of drug-metabolizing enzymes. To promote personalized medicine, we have carried out pharmacogenomics analysis and tried to develop genetic diagnostic drugs. In addition, we have established about 400 kinds of human recombinant CYP variant enzymes and are studying their functional differences to various drugs to estimate variation of pharmacokinetics due to genetic variations.
Figure 1. Allergic inflammation induced by environment/accessories
Figure 2. Promotion of personalized medicine by pharmacogenomics
- Asakawa S, et al. Nickel ions selectively inhibit lipopolysaccharide-induced interleukin-6 production by decreasing its mRNA stability. PLoS One 10:e0119428, 2015
- Segawa R, et al. Identification of a cell line producing high levels of TSLP: Advantages for screening of anti-allergic drugs. J Immunol Methods. 402:9-14, 2014
- Hiratsuka M, et al. Genetic polymorphisms of dihydropyrimidinase gene in a Japanese patient with capecitabine-induced toxicity. PLoS One. 10:e0124818, 2015
- Niinuma Y, et al. Functional characterization of 32 CYP2C9 allelic variants. Pharmacogenomics J. 14:107-114, 2014
- Ohsawa Y, Hirasawa, N. The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in Nc/Nga mice. Allergy. 67:1014-1022, 2012