Basic Medicine

Biobank Life Science

To Establish Comprehensive Biobank Science for Progression of Personalized Medicine and Health Care

Medical Sciences Course

  • Master / Doctoral Degree

Faculty

MINEGISHI, NaokoMINEGISHI, Naoko
MINEGISHI, Naoko

Professor, M.D. Ph.D.

  • TEL

    +81-22-272-3103

  • Mail

    nmine*med.tohoku.ac.jp (Please convert "*" into "@".)

*Concurrent Position

Research Theme

  • Quality improvement of biobank specimens
  • Innovation of management system of data and biospecimens
  • Effect of genetic polymorphism on characteristics of human cells
Research Keywords:

biobank, biospecimen, preanalytical factor, human genome, personalized medicine and health care

Technical Keywords:

quality management of biological specimens, cell-based research, genetic polymorphism and cellular characteristics, cryopreservation of biospecimen, laboratory information management system

Laboratory Introduction

The biobank of Tohoku Medical Megabank Organization (ToMMo) was established for storing biological specimens and health data from participants of cohort studies in Miyagi and Iwate prefectures as a part of the recovery plan from the Great East Japan Earthquake and Tsunami in 2011. Our Biobank will collect biospecimens from 150,000 participants of prospective community-based and family-based (three generation) cohort studies until 2017. We stored plasma, serum, urine, buffy coat cells and mononuclear cells from peripheral blood and cord blood. We automatically extracted genomic DNA from blood buffy coat cells and saliva. We equipped advanced Laboratory information management system and automatic system to deal with a lot of de-identified specimens with IDs linked to de-identified health data of participants. Currently, more than 2,700,000 specimens from 143,000 participants (December, 2016) have been accumulated in our biobank. These specimens will be used as resources to develop personalized medicine and health care. In order to improve the quality of biospecimens in our biobank, we are investigating for the improvement of management system of specimens and data. We are also searching for cell-based methods to explore the impact of genetic polymorphism on the risk to develop certain diseases.

Figure 1. Precise sample preparation system with barcoding and automation

Figure 1. Precise sample preparation system with barcoding and automation

Figure 2. Liquid nitrogen system for long term storage of biospecimen

Figure 2. Liquid nitrogen system for long term storage of biospecimen

Recent Publications

  • Minegishi N et al. Biobank Construction after Earthquake and Tsunami Disaster in Japan, Biopreserv Biobank 12:A-21, 2014
  • Motoike IN et al. Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population. BMC Genomics 15:673, 2014
  • Suzuki N et al. Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis Nat Commun 4:2902, 2013
  • Yamazaki S et al. A mouse model of adult-onset anaemia due to erythropoietin deficiency. Nat Commun 4:1950, 2013
  • Kon S et al. Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. M. J Clin Invest 123:1123-1137, 2013