Basic Medicine, Bioinformatics
Molecular Network Analysis
Providing Total Solution to the Whole Human Genome Analyses
Medical Sciences Course
- Master / Doctoral Degree
- YASUDA, Jun
Professor, M.D. Ph.D.
jyasuda*megabank.tohoku.ac.jp (Please convert "*" into "@".)
- Construction of Japanese genome reference panels
- Exploring the disease causing variants by population genetics
- Findings cancer specific genomic alterations
genome structures, population genetics, cancer genomics
next generation sequencers, SNP arrays, long-read sequencers
Our mission is to develop an infrastructure for realization of personalized prevention and medicine in the devastated areas by the great east Japan earthquake. To do so, we use genetic and omics information of the participants of prospective cohort in the damaged area to identify the susceptible loci for the common disease which is aggravating in the area. We have successfully sequenced the genomes of thousands of healthy participants and have constructed the whole-genome reference panel of Japanese population. Now we move to the analyses of relationship between genomic alterations and disease susceptibility and elucidation of molecular networks associated with disease mechanisms. We are expecting several millions of single nucleotide variants in an individual’s genome and some of them might be associated with disease onset. By means of integration of omics analyses, we will try to narrow down the candidate genes. Finally, we will try to identify disease susceptible genes for the cohort participants and give them the appropriate information for their health care.
Figure 1. The multi-omics approach to disease research
Figure 2. Next-generation sequencing platforms
- Nagasaki M, et al. Rare variant discovery by deep whole-genome sequencing of 1070 Japanese Individuals. Nat Commun. 6:8018, 2015.
- Yamaguchi-Kabata Y, et al. iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing. Hum Genome Var 2:15050, 2015
- Kawai Y, et al. Japonica Array: Improved genotype imputation by designing a population-specific SNP array with 1,070 Japanese individuals. J Hum Genet. 60(10):581-7, 2015.
- Katsuoka F, et al. An efficient quantitation method of next-generation sequencing libraries by using MiSeq sequencer. Anal Biochem. 466:27-29, 2014.?
- Motoike IN, et al. Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population. BMC Genomics 15:673, 2014.