Basic Medicine, Molecular and Cellular Biology

Oxygen Biology

Studies on Molecular Mechanisms of Oxygen-related Diseases through Elucidating Cellular Responses to Hypoxia and Hyperoxia



Associate Professor, Ph.D

*Concurrent Position

Research Theme

  • Mechanisms of Cellular Response to Hypoxic and Oxidative Stresses
  • Mechanisms of Hypoxia-inducible Erythropoietin Production
  • Effects of Anemic Hypoxia
Research Keywords:

Hypoxia, Oxidative Stress, Erythropoietin, Erythropoiesis, Renal Anemia

Technical Keywords:

Genetically Modified Mice, Exposure of Cells and Mice to Hypoxia, Transcriptional Regulation, Cell Sorting

Laboratory Introduction

Mammalian cells require oxygen for their energy homeostasis. But cells in solid tumors may survive in hypoxic microenvironment, where oxygen supply is blocked or instable due to abnormalities of the vascular networks. Such cells adapt to the chronic or intermittent hypoxic conditions through regulation of stress-responsive genes as well as energy metabolic pathways of the cells.
This project aims to understand molecular mechanisms involved in regulation of gene expression and energy metabolism in hypoxic cells using gene-modified mouse and biochemical strategies.

Figure 1. Renal Erythropoietin-producing Cells

Figure 1. Renal Erythropoietin-producing Cells

Recent Publications

  • Souma T, et al. Erythropoietin synthesis in renal myofibroblasts is restored by activation of hypoxia signaling. J Am Soc Nephrol. 27(2):428-438, 2016
  • Suzuki N, et al. Efficacy estimation of erythropoiesis-stimulating agents using erythropoietin-deficiency anemic mice. Haematologica 101(9): e356-e360, 2016
  • Tojo Y, et al. Hypoxia signaling cascade for erythropoietin production in hepatocytes. Mol Cell Biol. 35(15):2658-2672, 2015
  • Yamazaki S, et al. A mouse model of adult-onset anaemia due to erythropoietin deficiency. Nature Commun. 4: e1950, 2013
  • Suzuki N, et al. Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis. Nature Commun. 4: e2902, 2013