Tohoku university school of medicine

The focus of our work is the regulatory functions of immunoglobulin-like receptors (IgLRs), including Fc receptors (FcRs), paired immunoglobulin-like receptors (PIRs), leukocyte immunoglobulin-like receptors (LILRs), and other immunoreceptors. Our research programs include development of novel gene-targeted mice, generation of novel animal models for human diseases, dissection of relationship between immunoreceptors and diseases, fishing out novel receptors or subunit molecules involved in immunoregulation.
In addition to our focusing on research and discovery, we are also dedicated to quality education for young students. Each faculty member in the laboratory has his/her training research program(s) for students from faculties of Medicine, Science, Technology, Pharmaceutical Science and others. Under his/her watchful eye, students will learn to think creatively and work independently.

1) The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Prizes for Science and technology (Research Category) 2012 Role of Fc receptors in immune regulation

2) Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity. J. Exp. Med., 206: 1971-82, 2009

3) Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation. J. Exp. Med., 204: 907-20, 2007

4) Exacerbated graft-versus-host disease in Pirb-/- mice. Nat. Immunol., 5: 623-29, 2004

5) Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature, 428: 758-63, 2004

immunology, allergy, autoimmune, osteoclast, Immunoglobulin-like receptor, FcR, PIR, LILR, ITAM, ITIM