Tohoku university school of medicine

The laboratory is based on the electrophysiology evolving with the patch-clamp techniques providing a rapid and high-resolved data-set from membranes including the plasma, nuclear, and mitochondrial inner membrane. By maintaining a high quality of data-obtaining techniques, we have never hesitated to apply our techniques to any types of membranes, and have had experiences in pancreatic, salivary, and lacrimal acinar cells, blood platelets, megakaryocytes, mast cells, lymphocytes, adrenal gland cells, pericytes of microvessels, and a variety of cultured cells. At present we are interested in channels of nuclear envelopes (endoplasmic reticulum membranes) on one side, and the molecular structures of cloned voltage-gated Ca2+-channels on the other.

1)Calcium-activated potassium channels and their role in secretion Nature 307: 693-696 1984
2)Quantification of Ca2+-activated K+ channels under hormonal control in pig pancreas acinar cells Nature 305: 228-232 1983
3)Voltage and Ca2+-activated K+ channel in baso-lateral acinar cell membranes of mammalian salivary glands Nature 302: 827-829 1983
4)Cholecystokinin activation of single-channel currents is mediated by internal messenger in pancreatic acinar cells Nature 300: 61-63 1982
5)Single-channel currents in isolated patches of plasma membrane from basal surface of pancreatic acini Nature 299: 159-161 1982

exocrine cells, patch clamp, organella, ion channels