Tohoku university school of medicine

The Department of Pediatrics at Tohoku University School of Medicine was founded in 1918. The department is comprised of medical staff from Tohoku University School of Medicine as well as doctors in the pediatric department of the hospital; more than 30 doctors are working for clinical, educational and research activities of the department. The department has many clinical and research divisions focussing on: hematology, oncology and immunology, inborn errors of metabolism, endocrinology, neonatology, nephrology, neurology, and cardiology. Each group has highly motivated in its research and clinical work, and young staff members are given a stimulating environment in which to work.

1)Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.　　Nature. 448:1058-1062　　2007

2)Application of HSVtk suicide gene to X-SCID gene therapy: ganciclovir treatment offsets gene corrected X-SCID B cells.　　Biochem Biophys Res Commun. 341:391-398　　2006

3)WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).　　Proc Natl Acad Sci USA. 104:926-931　　2007

4)Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency　　J Pediatr. 135:375-378 　1999

5)Rapid diagnosis of glycine encephalopathy by 13C-glycine breath test　　Ann Neurol. 59:862-867　　2006

SCID, Wiskott-Aldrich syndrome, tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency, glycine encephalopathy, fetal pathophysiology, fetal organ injury, renal tubule, hypomyelination, congenital heart disease