The 68th Global COE Seminar 【Prof. Tapas K. Kundu】 (2/1)
Reversible histone acetylation plays a critical role in the transcription regulation of all the three RNA polymerases, predominantly polymerase II driven transcription. These include not only the transcription of protein coding gene but also the miRNA genes. We have found that a specific inhibition of histone acetyltransferase p300 alters the expression of a specific set of miRNA which are involved in diverse physiological functions.
Remarkably, we have found the activation of histone acetylation specifically in mice brain induces a very interesting set of genes which could be involved in neurogenesis and thereby the memory. The alteration of miRNA
expression due to the activation of specific histone acetyltransferase and its functional consequences are being investigated.
Lecturer： Prof. Tapas K. Kundu
(Jawaharlal Nehru Centre for Advanced Scientific Research - Professor）
「Activation of Histone Acetylation and Transcription Regulation in Brain」
Date and Time： February 1st, 2012 17:00-18:30
Venue： The 1st Seminar Room (2F), Tohoku University School of Medicine