News

2014.02.04 Press Release

Discovery of long lasting calcium oscillations in the neurons and glial cells of striatum of the basal ganglia

A research group led by Associate Professor Makoto Osanai and Researcher Atsushi Tamura of the Department of Radiological Imaging and Informatics at the Tohoku University Graduate School of Medicine has discovered a novel type of long lasting intracellular calcium oscillation in the striatum of the basal ganglia. As calcium plays a major role in the regulation of cellular function, this calcium oscillation may define the state of information processing within the brain. This calcium oscillation was lost by inhibiting the metabotropic glutamate receptor 5 and this receptor has been the therapeutic target for Parkinson's disease. Thus, this calcium oscillation might be related the pathology of Parkinson's disease. The research has been published online in the open access journal PLOS ONE. The paper's title
is "Both Neurons and Astrocytes Exhibited Tetrodotoxin-Resistant Metabotropic Glutamate Receptor-Dependent Spontaneous Slow Ca2+ Oscillations in Striatum."

[Contact]
(About the research)
Associate Professor Makoto Osanai
Laboratory of Radiological Imaging and Informatics
Tohoku University Graduate School of Medicine
TEL: +81- 22-717-7939 or 8684
E-mail: osanai*med.tohoku.ac.jp (Replace * with @)

(Public Relations)
Lecturer Hitoshi Inada
Public Relations Office of Tohoku University Graduate School of Medicine
TEL: +81-22-717-7891
FAX: +81-22-717-8187
E-mail: hinada*med.tohoku.ac.jp (Replace * with @)