News

2017.07.28 Press Release

Molecular imaging for coronary perivascular adipose tissue inflammation in the pathogenesis of coronary hyperconstricting responses in pigs in vivo

A research group led by Professor Hiroaki Shimokawa of the Department of Cardiovascular Medicine in Tohoku University Graduate School of Medicine and Professor Hiroshi Watabe of Cyclotron and Radioisotope Center, Tohoku University have reported molecular imaging by using 18F-FDG PET for coronary perivascular adipose tissue inflammation in the pathogenesis of coronary hyperconstricting responses in pigs in vivo.
Although coronary perivascular adipose tissue (PVAT) has been reported to play important roles as a source of inflammation, the association of coronary PVAT inflammation and coronary hyperconstricting responses remains to be examined. In this present study, we have demonstrated for the first time that inflammatory changes of coronary PVAT are associated with DES-induced coronary hyperconstricting responses in pigs in vivo and that 18F-FDG PET imaging is useful for assessment of coronary PVAT inflammation.
The research results have been published online in Arteriosclerosis, Thrombosis, and Vascular Biology on July27, 2017 (GTM). The paper’s title is “Association of Coronary Perivascular Adipose Tissue Inflammation and DES-induced Coronary Hyperconstricting Responses in Pigs -FDG PET Imaging Study-”

Publication Details:
Authors:Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Susumu Morosawa, Michinori Hirano, Hiroshi Watabe, Yoshihito Funaki, Satoshi Miyata, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa
Title: Association of Coronary Perivascular Adipose Tissue Inflammation and DES-induced Coronary Hyperconstricting Responses in Pigs -FDG PET Imaging Study-
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology

For enquiries about this research:
Hiroaki Shimokawa
Professor,
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Email: shimo@cardio.med.tohoku.ac.jp

For media enquiries:
Hitoshi Inada
Public Relations Office
Tohoku University Graduate School of Medicine
Tel: +81-22-717-7891
E-mail: hinada@med.tohoku.ac.jp