Basic Medicine, Molecular and Cellular Biology
To clarify the molecular basis of the interactions between the fatty acids and a number of physiological responses by focusing on the biological role of intracellular lipid binding proteins
Medical Sciences Course
- Master / Doctoral Degree
- OWADA, Yuji
Professor, M.D. Ph.D.
owada*med.tohoku.ac.jp (Please convert "*" into "@".)
- Role of cellular lipid homeostasis in the higher brain function
- Mechanism underlying cortical develoipment
- Role of intraepithelial lymphocytes in the digestive sysytem
fatty acid binding protein, lipid, cerebral cortex, lymphocyte, gene knockout mouse
immunohistochemistry, electronmicroscopy, cell culture, live cell imaging, gene targeting
Fatty acids are important nutrients for various biological reactions. Recent epidemiological evidence suggests that dietary consumption of some long chain fatty acids such as DHA and EPA, commonly found in fish oil, may modify the risk for certain disorders. However, the molecular basis of their actions is still to be clarified.
Long chain fatty acids (LCFA), are key players in cell functions, including membrane remodeling, control of receptor activity and signal transduction. Therefore it is to be expected that fatty acid binding proteins, due to their ability to binding LCFAs with high affinity, participate in neural, immune and other cell functions as modulators for their homeostatic regulation. The major goal of our laboratory is to clarify the molecular basis of the interactions between the fatty acids and a number of physiological responses by focusing on the biological role of intracellular lipid binding proteins.
Figure 1. Role of FABP in the cellular fatty acid metabolism
Figure 2. Regulation of membrane lipid raft formation by FABP7
- Kagawa, Y., et al. Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-1. Glia, 63, 780-794, 2015
- Islam, A., et al. Fatty acid binding protein 3 is involved in n-3 and n-6 PUFA transport in mouse trophoblasts. J Nutr, 144, 1509-1516, 2014
- Shimamoto, C., et al. Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. Hum Mol Genet, 23, 6495-6511, 2014
- Miyazaki, H., et al. Fatty acid binding protein 7 regulates phagocytosis and cytokine production in Kupffer cells during liver injury. Am J Pathol, 184, 2505-2515, 2014
- Shioda, N., et al. FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity. J Biol Chem, 289, 18957-18965, 2014