Basic Medicine, Molecular and Cellular Biology, Radiology and Bioimaging


Comprehensive Challenge on both Molecular Imaging from Basic Development to Clinical Application and Molecular and Psychopharmacological Research of Histamine

Medical Sciences Course

  • Master / Doctoral Degree


YANAI, KazuhikoYANAI, Kazuhiko
YANAI, Kazuhiko

Professor, M.D. Ph.D.

*Concurrent Position

Research Theme

  • Comprehensive molecular imaging study from basic probe screening to clinical application in humans
  • New functional study on histamine as a “good guy” using molecular and psychopharmacological methods
  • Development and application of early clinical diagnosis in Alzheimer disease using Positron Emission Tomography (PET)
Research Keywords:

molecular imaging, Alzheimer disease, drug development, histamine, positron emission tomography

Technical Keywords:

non-invasive molecular imaging, molecular and behavioral pharmacology, clinical study, genetically engineered mouse, neurochemistry

Laboratory Introduction

The Division is dedicated to carry out basic and clinical research at the highest quality, originality and creativity relevant to Pharmacology and Clinical Pharmacology. The Division is also committed to providing the highest quality of basic and clinical Pharmacology including appropriate ethical standards to medical students, graduate students, residents, fellows and researchers. Our main research topics are as follows: 1) Molecular pharmacology (main focus on histamine system). 2) Functional and molecular imaging in the living human brain by positron emission tomography (PET): the basic development and clinical application. 3) In vivo amyloid and tau imaging: their fundamental development and clinical application to Alzheimer disease. 4) Behavioral and neurochemical studies of histamine-related genes knockout mice. 5) Functions of the histaminergic neuron system in the CNS.

Figure 1. Roles of histamine on various functions as a good “guy”

Figure 1. Roles of histamine on various functions as a good “guy”

Figure 2. Molecular imaging by positron emission tomography in humans

Figure 2. Molecular imaging by positron emission tomography in humans

Recent Publications

  • Okamura N, et al. Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET. Brain. 2014; 137(Pt 6): 1762-1771
  • Yoshikawa T, et al. Molecular mechanism of histamine clearance by primary human astrocytes. Glia. 2013; 61(6): 905-916.
  • Nakamura T, et al. The expression and function of histamine H? receptors in pancreatic beta cells. Br J Pharmacol. 2014; 171(1): 171-185.
  • Yanai K, et al. Positron emission tomography evaluation of sedative properties of antihistamines. Expert Opinion on Drug Safety 2011; 10(4): 613-622.
  • Zhang D, et al. Next-day Residual Sedative Effect after Nighttime Administration of an OTC Antihistamine Sleepaid, Diphenhydramine, Measured by Positron Emission Tomography. J Clin Psychopharmacol 2010; 30(6): 694-701.