Clinical Medicine, Rehabilitation

Orthopaedic Surgery

Challenge to Reveal Unknown Pathology and Develop Novel Therapeutic Strategy for Orthopaedic Diseases: To Improve Patient’s Quality of Life

  • Master / Doctoral Degree

Faculty

AIZAWA, ToshimiAIZAWA, Toshimi
AIZAWA, Toshimi

Professor, M.D., Ph.D.

Research Theme

  • Biomechanical studies of the shoulder joint and development of novel clinical assessment and treatment of rotator cuff tear
  • Analyses of bone metabolism and fracture healing and development of novel prosthesis for hip joint
  • Analysis of molecular mechanism in neural tissue damage and development of novel therapeutic strategy for spinal cord injury
Research Keywords:

shoulder joint, bone metabolism, osteoporosis, spinal cord injury

Technical Keywords:

biomechanical analysis, molecular biological analysis, histological analysis, finite element method

Laboratory Introduction

In shoulder group, we are perfoming biomechanical studies using fresh frozen cadavers. We are trying to clarify the stabilizing mechanisms of the shoulder and to evaluate the initial strength of rotator cuff repair with use of the latest magnetic sensor, strain sensor and MTS machine.
The hip and knee group is developing a new system of total hip arthroplasty using new low Young's modulus alloy. We evaluate safety and efficacy of the new material with animal experimental models and perform clinical trial of new prosthesis. We also analyze bone fracture healing with suppression of inflammation and osteoclast function for delineation of therapeutic procedure of failed bone union (Figure1).
The cartilage biology group is aiming to clarify the pathogenesis or mechanism of progression of osteoarthritis (OA). We are investigating gene control of cartilage-destroying proteins related to OA via DNA methylation, one of epigenetic mechanisms.
The spinal cord injury research group is aiming to reveal molecular mechanism in neural tissue damage and develop novel therapeutic strategy for spinal cord injury. We try to clarify the novel cell death mechanism associated with autophagy and necroptosis. We also evaluate clinical usefulness of extra-corporeal shock wave therapy and mTOR inhibitor for treatment of spinal cord injury (Figure2).

Figure 1. Stem cell differentiation in fracture healing

Figure 1. Stem cell differentiation in fracture healing

Figure 2. Novel cell death mechanism after spinal cord injury

Figure 2. Novel cell death mechanism after spinal cord injury

Recent Publications

  • 1.Yahata K, et al. Low-energy extracorporeal shock wave therapy for promotion of vascular endothelial growth factor expression and angiogenesis and improvement of locomotor and sensory functions after spinal cord injury. J Neurosurg Spine. 25(6):745-755, 2016.
  • 2.Tateda S, et al. Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury. J Orthop Res. 2016. doi: 10.1002/jor.23328.
  • 3.Hatta T, et al. Comparison of Passive Stiffness Changes in the Supraspinatus Muscle After Double-Row and Knotless Transosseous-Equivalent Rotator Cuff Repair Techniques: A Cadaveric Study. Arthroscopy. 32(10):1973-1981, 2016. doi: 10.1016/j.arthro.2016.02.024.
  • 4.Tanaka H, et al. Apatite Formation and Biocompatibility of a Low Young's Modulus Ti-Nb-Sn Alloy Treated with Anodic Oxidation and Hot Water. PLoS One. 25;11(2):e0150081, 2016. doi: 10.1371/journal.pone.0150081.
  • 5.Kamimura M, et al. Impaired Fracture Healing Caused by Deficiency of the Immunoreceptor Adaptor Protein DAP12.PLoS One. 1;10(6):e0128210, 2015. doi: 10.1371/journal.pone.0128210.