Clinical Medicine, Public Health

Emerging and Reemerging Infectious Diseases(National Center for Global Health and Medicine)

The Research and Development of Diagnosis, Treatment, and Prevention of Emerging and Re-emerging Infectious Diseases through medical practice and Epidemiological Study

Medical Sciences Course



Professor, M.D., M.Sc., Ph.D.

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Research Theme

  • Management of emerging and re-emerging infectious diseases
  • Preparedness for emerging and re-emerging infectious diseases
  • Healthcare-associated infections and antimicrobial resistance
Research Keywords:

Emerging and re-emerging infectious diseases, Risk Management, Antimicrobial resistance, Healthcare associated infections

Technical Keywords:

Genome sequencing, Microbiological diagnosis utilizing multiplex PCR, Healthcare Epidemiology

Laboratory Introduction

Field of infectious disease has spread from individual patient's health problems to the global level. Subjects are extremely diverse, ranging from diagnosis and treatment of individual patients, to prevention and public health measures. To function as a clinical referral center for infectious diseases in Japan, Disease Control and Prevention Center at the National Center for Global Health and Medicine put emphasis on 1) clinical management, 2) focus on human resource development / training of infectious diseases area, 3) networking, 4) research centers at home and abroad of infection, 5)healthcare epidemiology, and carried out a comprehensive and multi-faceted, innovative initiatives related to domestic and international infectious diseases.
The main research themes are 1)diagnosis using the genomic approach emerging re-emerging infectious diseases, 2)treatment and prevention of emerging re-emerging infectious diseases, 3) preparedness for emerging infectious diseases at healthcare facilities, 4) psychosocial factors and method of risk communication, 5) antibiotic-resistant bacteria infection, 6) imported infectious diseases such as malaria, dengue fever, typhoid fever.

Figure 1. Giemsa stained image of Plasmodium falciparum

Figure 1. Giemsa stained image of Plasmodium falciparum

Figure 2. Training session for emerging infectious diseases

Figure 2. Training session for emerging infectious diseases

Recent Publications

  • Binh NG, Hayakawa K, Co DX, Tuan ND, Anh NH, Thuy NT, Phuong DM, Huong NT, Thuy PT, Chau NQ, Nhung PH, Gam do TH, Hai DT, Huong TT, Van Anh L, Takeshita N, Ohmagari N. The efficacy and nephrotoxicity associated with colistin use in an intensive care unit in Vietnam: Use of colistin in a population of lower body weight. Int J Infect Dis. 2015 Jun;35:18-23. doi: 10.1016/j.ijid.2015.03.020. Epub 2015 Mar 30. PubMed PMID: 25835100.
  • Sherchan JB, Hayakawa K, Miyoshi-Akiyama T, Ohmagari N, Kirikae T, Nagamatsu M, Tojo M, Ohara H, Sherchand JB, Tandukar S. Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648. Antimicrob Agents Chemother. 2015;59(6):3424-32. doi: 10.1128/AAC.00270-15. Epub 2015 Mar 30. PubMed PMID: 25824221; PubMed Central PMCID: PMC4432170.
  • Kutsuna S, Kato Y, Moi ML, Kotaki A, Ota M, Shinohara K, Kobayashi T, Yamamoto K, Fujiya Y, Mawatari M, Sato T, Kunimatsu J, Takeshita N, Hayakawa K, Kanagawa S, Takasaki T, Ohmagari N. Autochthonous dengue fever, Tokyo, Japan, 2014. Emerg Infect Dis. 2015 Mar;21(3):517-20. doi: 10.3201/eid2103/141662. PubMed PMID: 25695200; PubMed Central PMCID: PMC4344289.
  • Hayakawa K, Miyoshi-Akiyama T, Kirikae T, Nagamatsu M, Shimada K, Mezaki K, Sugiki Y, Kuroda E, Kubota S, Takeshita N, Kutsuna S, Tojo M, Ohmagari N. Molecular and epidemiological characterization of IMP-type metallo-β-lactamase-producing Enterobacter cloacae in a Large tertiary care hospital in Japan. Antimicrob Agents Chemother. 2014 Jun;58(6):3441-50. doi: 10.1128/AAC.02652-13. Epub 2014 Apr 7. PubMed PMID: 24709261; PubMed Central PMCID: PMC4068452.
  • Kutsuna S, Hayakawa K, Kato Y, Fujiya Y, Mawatari M, Takeshita N, Kanagawa S, Ohmagari N. The usefulness of serum C-reactive protein and total bilirubin levels for distinguishing between dengue fever and malaria in returned travelers. Am J Trop Med Hyg. 2014 Mar;90(3):444-8. doi: 10.4269/ajtmh.13-0536. Epub 2014 Jan 13. PubMed PMID: 24420780; PubMed Central PMCID: PMC3945689.