2013.06.13 Press Release

Nanorobot created through virus derived peptide

A research group led by Senior Assistant Professor Yasuhiro Suzuki of the Tohoku University Hospital discovered that nanoparticles can be given attributes of nanorobots through layering 8 virus derived peptides on the surface of fluorescent nanoparticles known as quantum dots.

Medical treatments using nanoparticles have been anticipated to be a revolutionary medical technology in the 21st century. In this study, Senior Assistant Professor Suzuki and his group demonstrated that when the number of virus derived peptides linked per nanoparticle is eight, nanoparticles have the ability to behave as cargo-delivery nanomachines with the ability to induce local events to activate cellular machinery, allowing each particle to move on the cell surface and be internalized inside the cells. Utilizing similar methods, various types of nanoparticles, polymer compounds, and macromolecular drugs can be expected to be turned into nanorobots which can efficiently get inside cells. This technology can be expected to contribute to further developments in medical technology utilizing nanoparticles.

This research was made possible with grants from the "Challenging Exploratory Research" program of the Japan Society for the Promotion Science and the "Adaptable and Seamless Technology Transfer Program through Target Driven R & D" (A-STEP) program of the Japan Science and Technology Agency. This research was conducted with collaboration from the Graduate School of Biomedical Engineering at Tohoku University, The National Institute of Advanced Industrial Science and Technology, and the School of Science at University of Tokyo. The results of this research were published on June 3, 2013 (U.S. Time) in the electronic edition of Molecular and Cellular Biology and will be published in the August issue of its print edition. The paper's title is "Single quantum dot tracking reveals that an individual multivalent HIV-1 Tat-protein transduction domain can activate machinery for lateral transport and endocytosis."

(About the research)
Senior Assistant Professor Yasuhiro Suzuki
Department of Emerging Infectious Diseases, Tohoku University Hospital
TEL: +81-22-717-8220
E-mail: suzukiy39* (Replace * with @)

(Public Relations)
Associate Professor Fuji Nagami
Public Relations Office of Tohoku University Graduate School of Medicine
TEL: +81-22-717-7908
FAX: +81-22-717-8187
E-mail: f-nagami* (Replace * with @)