2013.07.01 Press Release
Elucidation of the mechanism of the unexplained cerebral infarction associated with aortosclerosis
Associate Professor Junichiro Hashimoto of the Department of Blood Pressure Research and Professor Sadayoshi Ito of the Division of Nephrology, Endocrinology and Vascular Medicine of the Tohoku University School of Medicine have newly elucidated the pathogenic mechanism of the unexplained cerebral infarction associated with aortic stiffening.
It is known that high blood pressure is a major risk factor for stroke. Associate Professor Hashimoto’s group measured the blood flow of the descending thoracic aorta in hypertensive patients and discovered for the first time a retrograde blood flow towards the cranial direction is present in the aorta during cardiac diastole. In addition, this retrograde blood flow increases as aortic stiffness progresses. The presence of this aortic blood flow reversal strongly suggests the possibility of retrograde embolic stroke resulting from plaque and blood clots formed in the descending thoracic aorta which is then carried to the brain artery through the carotid artery.
The research results will be published in the September issue of the journal of the American Heart Association, Hypertension. The paper's title is "Aortic stiffness determines diastolic blood flow reversal in the descending thoracic aorta: Potential implication for retrograde embolic stroke in hypertension."
More information (Japanese)
(About the research)
Associate Professor Junichiro Hashimoto
Department of Blood Pressure Research
Tohoku University Graduate School of Medicine
E-mail: hashimoto*med.tohoku.ac.jp (Replace * with @)
Lecturer Hitoshi Inada
Public Relations Office of Tohoku University Graduate School of Medicine
TEL: +81-22-717-7891 FAX: +81-22-717-8187
E-mail: hinada*med.tohoku.ac.jp (Replace * with @)