News

2013.07.25 Press Release

Discovery of new therapeutic effects in drugs used for hyperlipidemia treatment

Statins is a drug used by about 30 million people worldwide in treating hyperlipidemia and is also used in preventing and treating cardiovascular disorders such as myocardial infarctions. Recently, it has been discovered that statins, while effective in lowering cholesterol, has other therapeutic effects in preventing cardiovascular diseases termed as “pleotropic effect”. A research group led by Professor Hiroaki Shimokawa of the Department of Cardiovascular Medicine at the Tohoku University School of Medicine discovered, for the first time in the world, that the small GTP-binding protein GDP dissociation stimulator (SmgGDS) plays a central role in the molecular mechanism that causes this pleotropic effect. New drugs to combat cardiovascular diseases could be developed by increasing this SmgGDS molecule, and the creation of genetic markers to predict the onset of cardiovascular diseases may also be possible with the results of this research.

More information (Japanese)

[Contact]
Professor Hiroaki Shimokawa
Department of Cardiovascular Medicine
Tohoku University Graduate School of Medicine
TEL: +81-22-717-7151
E-mail: shimo*cardio.med.tohoku.ac.jp (Replace * with @)

[Public Relations]
Lecturer Hitoshi Inada
Public Relations Office of Tohoku University Graduate School of Medicine
TEL: +81-22-717-7891
FAX: +81-22-717-8187
E-mail: hinada*med.tohoku.ac.jp (Replace * with @)