2013.10.15 Press Release
Identification of transcription factors that contribute to lung function maintenance: Dysfunction of gene expression system leads to onset of pulmonary alveolar proteinosis
The joint research group consisting of Professor Kazuhiko Igarashi of the Department of Biochemistry, Tohoku University Graduate School of Medicine and Professor Emeritus Toshihiro Nukiwa of the Department of Respiratory Medicine, Tohoku University Graduate School of Medicine discovered the gene expression system required for the maintenance of homeostasis in the lungs and its dysfunction is involved in the development of pulmonary alveolar proteinosis.
In many organisms including humans, the ability of the lungs to capture the oxygen in the air is dependent on a substance called the alveolar surfactant that is present in the lungs. However, an excessive accumulation of the alveolar surfactant results in a disease called pulmonary alveolar proteinosis which includes symptoms such as difficulty in breathing. The research group elucidated the gene expression system required for the maintenance of homeostasis of the alveolar surfactants and discovered one of the causes of pulmonary alveolar proteinosis.
The results of this research will be published in the American medical journal, Journal of Experimental Medicine. The paper's title is "Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function."
More information (Japanese)
(About the research)
Professor Kazuhiko Igarashi
Department of Biochemistry, Tohoku University Graduate School of Medicine
E-mail: igarashi*med.tohoku.ac.jp (Replace * with @)
Lecturer Hitoshi Inada
Public Relations Office of Tohoku University Graduate School of Medicine
E-mail: hinada*med.tohoku.ac.jp (Replace * with @)