2013.12.24 Press Release
Short-term fasting and insulin injection increases the effect of islet transplantation Performance improvements to cell transplantation in diabetes treatment
The research group led by Professor Masafumi Goto, New Industry Creation Hatchery Center at Tohoku University (Concurrent post: Tohoku University School of Medicine), Professor Noriaki Ohuchi, Division of Advanced Surgical Science and Technology at the Tohoku University School of Medicine and Dr. Takuya Jimbo established that in islet transplantation therapy to target diabetes post-transplant short-term fasting and insulin injection dramatically increases the effectiveness of the islet transplantation. Past studies have shown approximately 2 weeks are needed for the recipient body to complete the feeding arteries to the transplanted islet cells. Therefore, the study postulated that preventing the exhaustion of transplanted islet cells during this period lacking nutrients and oxygen was crucial to improve the success rate of transplantation. Then, a new surgical technique was devised using this approach and its effectiveness was confirmed. The research results are expected to be extremely useful in building a future performance improvement strategy of islet transplantation therapy.
The research results were published in the online version of the American academic journal Transplantation on November 25 (EST). The paper's title is "A Novel Resting Strategy for Improving Islet Engraftment in the Liver."
(About the research)
Professor Masafumi Goto
New Industry Creation Hatchery Center, Tohoku University
Laboratory of Advanced Cell Transplantation, Tohoku University Graduate School of Medicine
E-mail: goto*niche.tohoku.ac.jp (Replace * with @)
Lecturer Hitoshi Inada
Public Relations Office of Tohoku University Graduate School of Medicine
E-mail: hinada*med.tohoku.ac.jp (Replace * with @)