2016.02.04 Press Release

Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites

A research group led by Professor Noriko Osumi of the Department of Developmental Neuroscience at the Tohoku University Graduate School of Medicine has clarified the effect of excess omega-6 fatty acid intake by pregnant female mice on the offspring.

The research group showed that feeding an n-6 excess/n-3 deficient diet by pregnant mice was resulted in impaired neocortical neurogenesis of the offspring. A systematic mediator lipidomics screen identified key mediators including epoxy metabolites. Interestingly, although the offspring were raised on a well-balanced n-6:n-3 diet, they showed more anxiety-related behavior compared with control animals. These findings strongly indicated that excess maternal intake of n-6 PUFAs combined with insufficient intake of n-3 PUFAs causes abnormal brain development that can have long-lasting effects on the offspring's mental state. The research results have been published in the online version of the Stem Cells.

More information

(About the research)
Professor Noriko Osumi
Department of Developmental Neuroscience, Center for Neuroscience
United Centers for Advanced Research and Translational Medicine
Tohoku University School of Medicine
Tel: +81-22-717-8203
Email: osumi* (Replace * with @)

(Pubilic Relations)
Hitoshi Inada
Public Relations Office
Tohoku University School of Medicine
Tel: +81-22-717-7891
Email: hinada* (Replace * with @)