脳神経科学を社会へ還流する教育研究拠点　東北大脳科学グローバルCOE

Neuroprotection in brain injury and stroke- the role of protein ubiquitination and exosomes -

Dr. Seong-Seng Tan (Howard Florey Institute, University of Melbourne, Australia)

We have discovered a new protein, Ndfip1, that is critical for protecting neurons from apoptosis during stress injury. Ndfip1 upregulation in central neurons is a generic protective response during brain trauma, stroke and retinal ischemia. This talk will discuss the molecular mechanisms of Ndfip1 neuroprotection, and provide evidence for rapid protein disposal by ubiquitination and exosome export.

Gunnersen JM, Kim MH, Fuller SJ, De Silva M, Britto JM, Hammond VE, Davies PJ, Petrou S, Faber ES, Sah P, Tan SS (2007)
Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons. Neuron 56(4):621-639

Hammond V, So E, Gunnersen J, Valcanis H, Kalloniatis M and Tan SS (2006)_ Layer positioning of late-born cortical interneurons is dependent upon Reelin but not p35 signaling._J Neurosci 26:1646-1655

Britto JM, Obata K, Yanagawa Y and Tan SS (2006) _Migratory response of interneurons to different regions of the developing cortex._Cereb. Cortex 16:i57-63

Sang Q, Kim M, Kumar S, Bye B, Morganti-Kossman MC, Gunnersen J, Fuller S,　Howitt J, Hyde L, Beissbarth T, Scott HS, Silke J and Tan SS (2006)_ Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival following acute cortical brain injury._J Neurosci 26:7234-7244

Kim MH, Gunnersen JM and Tan SS (2005) Mph2 expression in germinal zones of the mouse brain Dev. Dyn 232:209-215

George AJ, Holsinger RM, McLean CA, Tan SS, Scott HS, Cardamone T, Cappai R, Masters CL and Li QX (2005) Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576　mouse model of Alzheimer's disease. Neurobiol. Aging 27:614-623

創生応用医学研究センター　形態形成解析分野 (大隅典子)
022-717-8203　
内線8203