東北大学大学院医学系研究科・医学部

STAFF

Professor

• Goto, MasafumiProfessor. 後藤 昌史 教授
  

Other Faculty / Staff

• Inagaki, Akiko

  Assistant Prof. 稲垣 明子 助教

CONTACT

OUTLINE

Transplant medicine and regenerative medicine are closely related, and it is expected that regenerative medicine will effectively solve various problems that the current transplant medicine holds. Given that most of the current regenerative medicine takes the form of cell therapy, the findings obtained from cell transplantation are extremely useful for the effective cooperation between transplantation medicine and regenerative medicine, and cell transplantation is considered to have important significance as a bridge between transplantation medicine and regenerative medicine. Pancreatic islet transplantation, a typical example of such cell transplantation therapy, is an ideal minimally invasive treatment for patients with severe type 1 diabetes who suffer from glycemic control. Hepatocyte transplantation is also a minimally invasive cell therapy aimed at treating liver failure and metabolic diseases, and has the characteristic of being able to utilize many of the technologies and knowledges established in pancreatic islet transplantation. However, it is crucial for islet transplantation and hepatocyte transplantation to combine with regenerative medicine to expand these attractive treatments to more patients in the future. In our devision, we are working on "establishment of a novel subcutaneous transplantation method" and "development of immunoisolated cell devices", which are regarded as the key factors to that purpose, and are advancing research with the aim of establishing next-generation cell therapy by effective fusion with regenerative medicine.

移植医療と再生医療は元来密接に関連しており、現行の移植医療が抱える様々な課題を、今後再生医療が効果的に解消していくことが期待されています。しかし現状における再生医療はその殆どが細胞治療の様式をとるため、移植医療と再生医療の有機的連携には特に細胞移植で得られる知見が極めて有用であり、細胞移植は移植医療と再生医療を橋渡しする重要な意義を有していると考えられます。膵島移植はそのような細胞移植の典型例であり、血糖コントロールに苦しむ重症1型糖尿病患者にとり、まさに理想的な患者に優しい治療法です。また肝細胞移植も肝不全や代謝性疾患の治療を目的とした低侵襲細胞治療であり、膵島移植で確立した技術や知見の多くを活用できるという特徴を有しております。これらの治療法を今後より多くの重症糖尿病患者や代謝性肝疾患患者へ提供していくには、再生医療との融合が不可欠ですので、当分野においては、そのための鍵となる“新規皮下移植法の樹立”や”免疫隔離細胞デバイスの開発”に取り組み、再生医療との効果的融合による次世代細胞治療の確立を目指して研究を進めております。

• 

  Fusion of transplant medicine and regenerative medicine
  移植医療と再生医療の融合

• 

  Subcutaneous islet transplantation method by introducing a novel scaffold
  新規素材を用いた皮下膵島移植法

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  Division-hosted academic congress (left) and cell culture laboratory (right)
  教室による主催学会（左）と培養実験室（右）

ARTICLE

Yamana H, et al. Cotransplantation with adipose tissue-derived stem cells improves engraftment of transplanted hepatocytes.
Transplantation. 2022 Apr 11 (Online ahead of print)
URL：https://journals.lww.com/transplantjournal/Fulltext/9900/Cotransplantation_With_Adipose_Tissue_Derived_Stem.20.aspx

Nishimaki H, et al. Short-term inhalation of isoflurane improves the outcomes of intraportal hepatocyte transplantation.
Sci Rep. 12(1):4241: 2022
URL：https://www.nature.com/articles/s41598-022-08237-6

Ogasawara H, et al. Preferable transplant site for hepatocyte transplantation in a rat model.
Cell Transplantation. Jan-Dec 30:9636897211040012:202
URL：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450989/

Fathi I, et al. KRP-203 is a desirable immunomodulator for islet allotransplantation.
Transplantation. Jul 1: 2021 (Online ahead of print)
URL：https://journals.lww.com/transplantjournal/Abstract/9000/KRP_203_is_a_Desirable_Immunomodulator_for_Islet.95212.aspx

Matsumura M, et al. A Simple and useful predictive assay for evaluating the quality of isolated hepatocytes for hepatocyte transplantation.
Sci Rep. 9(1):6166: 2019
URL：https://www.nature.com/articles/s41598-019-42720-x

LINK

• 令和5年度 辛酉優秀学生賞授与式が行われました
• 移植再生医学分野の大学院生斉藤竜助氏が第50回日本膵・膵島移植学会において学会賞を受賞
• 膵島移植後の副作用が少ない免疫抑制剤 - 糖尿病治療のための膵島移植に最適な新規免疫抑制剤を同定–