医科学専攻
- Doctoral Courses
博士課程
Neurological and Psychiatric Sciences / Functional Neurosurgery(National Center of Neurology and Psy脳神経精神医学講座 / 機能神経外科学（国立精神・神経医療研究センター）
STAFF
Professor
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Iwasaki, MasakiProfessor. 岩崎 真樹 教授
CONTACT
TEL：+81-42-341-2711
E-MAIL：iwa*ncnp.go.jp
（「*」を「@」に変換してください）
OUTLINE
Our department conducts clinical research in the field of functional neurosurgery, especially on epilepsy surgery and deep brain stimulation. Epilepsy is one of the most prevalent neurological diseases, and there are about 1 million patients in Japan. About 30% of these patients have drug-resistant seizures, for whom surgical treatment is indicated. Our research topics include the efficacy of early surgery in infants and children with epilepsy, the development of minimally invasive surgical techniques, the relationship between diagnostic imaging (MRI, PET, etc.) and surgical outcomes, and functional analysis of the brain using intracranial EEG data. We are also conducting genomic analysis of epileptogenic tumors and malformation of cortical development using surgical specimens registered in the NCNP Biobank, which is aimed at elucidating new diagnostic methods and pathogenesis. We also investigate the efficacy of deep brain stimulation for movement disorders such as Parkinson\'s disease and Tourette\'s syndrome in cooperation with the Departments of Neurology and Psychiatry.
当科では機能的脳神経外科領域の臨床研究を行なっています。てんかんは有病率の最も高い神経疾患の一つで、国内には約100万人の患者がいるとされます。そのうち約30%は薬物でてんかん発作がコントロールされない難治性てんかんであり、外科治療が適応になります。乳幼児期や発症早期に行う外科治療の有効性や低侵襲手術手技の開発、MRIやPETなどの画像診断と治療予後の関係、頭蓋内脳波を用いた脳機能解析といったテーマで研究を行っています。また、バイオバンクに登録した外科検体を用いててんかん原性腫瘍や皮質形成異常のゲノム解析を実施し、新しい診断法や病態解明を目指した研究にも取り組んでいます。パーキンソン病やトゥレット症候群など不随意運動に対する脳深部刺激療法は、脳神経内科など他部門と協力して臨床研究を展開しています。
Electroencephalographic seizure recorded from stereotactically-implanted intracranial electrodes
定位的頭蓋内脳波に記録されたてんかん発作
ARTICLE
Iwasaki M, et al. Epilepsy surgery in children under 3 years of age: surgical and developmental outcomes. J Neurosurg Pediatr. 1-9, 2021. [Epub ahead of print]
Takayama Y, et al. Single-Institutional Experience of Chronic Intracranial Electroencephalography Based on the Combined Usage of Subdural and Depth Electrodes. Brain Sci. 11(3):307, 2021.
Kimura Y, et al. Deep Brain Stimulation for Refractory Tourette Syndrome: Electrode Position and Clinical Outcome. Neurol Med Chir (Tokyo). 61(1):33-9, 2021.
Ikegaya N, et al. Cognitive and developmental outcomes after pediatric insular epilepsy surgery for focal cortical dysplasia. J Neurosurg Pediatr. 26(5):543-51, 2020.
Takayama Y, et al. Is intracranial electroencephalography useful for planning resective surgery in intractable epilepsy with ulegyria J Neurosurg. 133(5):1576-81, 2021.
