医科学専攻
- Master's Courses
修士課程 - Doctoral Courses
博士課程
Division of Advanced Cerebrovascular Surgery先進脳血管外科学講座（広南会広南病院）
STAFF
Professor
CONTACT
TEL：+81-22-248-2131
E-MAIL：h-endo*nsg.med.tohoku.ac.jp
（「*」を「@」に変換してください）
OUTLINE
It is our distinct pleasure to welcome all the young investigators, being interested in the cerebrovascular surgeries for intracranial aneurysms, Moyamoya disease, and brain vascular malformations. We are particularly focusing our interests on the basic pathology and perioperative cerebral hemodynamics in patients with Moyamoya disease. Cerebral blood flow measurement after revascularization surgery for Moyamoya disease significantly contributed to the understanding of the intrinsic and complex perioperative pathology of Moyamoya disease, and has markedly improved the outcome of surgery during the past 10 years. We are also focusing on the basic pathology of intracranial aneurysms and their growth/rupture using high-resolution MRI vessel wall imaging technique, which is now clinically applied to evaluate the risk of future aneurysm growth and/or rupture in each patient. We are also conducting clinical/basic research of dissecting aneurysms and brain vascular malformations.
当科では、近年発展が目覚しい脳血管障害に対する外科治療を入口として、脳動脈瘤、もやもや病、脳血管奇形などの脳血管疾患における新規治療開発・病態研究・脳循環代謝研究を行っています。特に、若年者脳卒中の原因として近年増加傾向にあるもやもや病に関しては半世紀以上にわたる当科での診療経験を踏まえて、遺伝子研究やバイパス手術に際しての周術期病態の解明を中心に先進的研究を推進しています。また、くも膜下出血の原因として重要な脳動脈瘤に関しては高感度MRIを用いた動脈瘤壁イメージング（vessel wall imaging）やコンピューター流体解析（computational fluid dynamics）を駆使した動脈瘤増大・破裂に関する病態研究を進めています。
Intraoperative photo of bypass surgery for Moyamoya disease
もやもや病に対するバイパス術中写真
Intraoperative photo of clipping surgery for intracranial aneurysm
脳動脈瘤に対するクリッピング術の術中写真
Intraoperative photo of clipping surgery for intracranial aneurysm
脳動脈瘤に対するクリッピング術の術中写真
ARTICLE
Ozaki D, et al. Association between RNF213 c.14576G>A Variant (rs112735431) and Peripheral Pulmonary Artery Stenosis in Moyamoya Disease. Cerebrovasc Dis. 2021 Oct 28:1-6. doi: 10.1159/000519717. Epub ahead of print. PMID: 34710878.
Endo H, et al. Efficacy of arterial spin labeling magnetic resonance imaging with multiple post-labeling delays to predict postoperative cerebral hyperperfusion in carotid endarterectomy. Neurol Res. 2021 Mar;43(3):252-258. doi: 10.1080/01616412.2020.1847529. Epub 2020 Nov 15. PMID: 33190623.
Endo H et al. Risk factors for medullary infarction after endovascular trapping of vertebral artery dissecting aneurysms. Neurosurg Rev. 2021 Aug;44(4):2283-2290. doi: 10.1007/s10143-020-01424-x. Epub 2020 Oct 21. PMID: 33083928.
Endo H, et al. Optimal Timing of Extracranial-Intracranial Bypass with Microsurgical Trapping for Ruptured Blister Aneurysms of the Internal Carotid Artery. World Neurosurg. 2020 Apr;136:e567-e577. doi: 10.1016/j.wneu.2020.01.081. Epub 2020 Jan 17. PMID: 31958590.
Omodaka S et al. Circumferential wall enhancement in evolving intracranial aneurysms on magnetic resonance vessel wall imaging. J Neurosurg. 2018 Oct 1:1-7. doi: 10.3171/2018.5.JNS18322. Epub ahead of print. PMID: 30485237.
