医科学専攻 公衆衛生学専攻
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博士課程
Clinical Epidemiology（Tohoku Medical Megabank Organization）臨床疫学分野（東北メディカル・メガバンク機構）
STAFF
Professor
-
Obara, TakuProfessor.Ph.D. 小原 拓 教授 (兼任)
Other Faculty / Staff
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Orui, Masatsugu
Assoc. Prof.M.D. Ph.D. 大類 真嗣 准教授（兼任） -
Ishikuro, Mami
Lect.Ph.D. 石黒 真美 講師（兼任） -
Noda, Aoi
Assistant Prof.Ph.D. 野田 あおい 助教（兼任） -
Shinoda, Genki
Assistant Prof.Ph.D. 篠田 元気 助教（兼任）
CONTACT
TEL：＋81-22-717-8103
E-MAIL：taku.obara.a5*tohoku.ac.jp
（「*」を「@」に変換してください）
OUTLINE
The Department of Clinical Epidemiology aims to generate evidence that bridges population-based research and clinical practice. Our laboratory promotes a unique multigenerational cohort platform, the TMM Birth and Three-Generation Cohort Study, to elucidate how genetic, environmental, behavioral, and social factors across generations influence health and disease throughout the life course.
Our major research areas include perinatal epidemiology, life-course epidemiology, and perinatal pharmacoepidemiology. We investigate the safety and effectiveness of medication use during pregnancy and lactation, maternal and child health outcomes, developmental origins of health and disease (DOHaD), and intergenerational transmission of disease risk. By integrating epidemiological methods with genomics, multi-omics, and real-world clinical data, we seek to identify novel determinants of health and disease from fetal life to adulthood.
A central mission of our laboratory is the translation of epidemiological findings into clinical and public health practice. We aim not only to advance scientific understanding, but also to contribute to precision medicine, evidence-based perinatal care, and preventive strategies that improve the health of future generations.
臨床疫学分野では、コホート研究から得られる知見を臨床現場へ還元することを目指し、エビデンス創出と社会実装を推進しています。特に、出生三世代コホート調査を基盤として、胎児期から成人期に至るライフコース全体を見据えた研究を展開しています。主な研究領域は、周産期疫学、ライフコース疫学、周産期薬剤疫学であり、妊娠・授乳期の医薬品安全性評価、母子保健、生活習慣病発症リスク、遺伝要因と環境要因の相互作用などを解析しています。さらに、ゲノム・マルチオミックス解析やリアルワールドデータを活用し、次世代の予防医療や個別化医療につながる研究を推進しています。
Research meeting
研究ミーティング
Staff
教員
Int J Epidemiol. 2025;54(5):dyaf148.
三世代コホート調査の概要
J Dev Orig Health Dis. 2025:16:e46.
祖母の妊娠中の喫煙と孫の在胎不当過小
ARTICLE
Ishikuro M, et al. Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Hypertens Res. 2025 Jan;48(1):68-76.
URL：https://pubmed.ncbi.nlm.nih.gov/39394519/
Orui M, et al. Longitudinal association between the duration of eye gaze fixation on social information and specific symptoms of neurodevelopmental disorders in children: A large-scale community-based cohort study. PCN Rep. 2025 May 19;4(2):e70095.
URL：https://pubmed.ncbi.nlm.nih.gov/40391067/
Obara T, et al. Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update. Int J Epidemiol. 2025 Aug 18;54(5):dyaf148.
URL：https://pubmed.ncbi.nlm.nih.gov/40971469/
Shinoda G, et al. Genome-Wide Association Study of Cognitive Function in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study. Genes Brain Behav. 2025 Oct;24(5):e70038.
URL：https://pubmed.ncbi.nlm.nih.gov/41108541/
Noda A, et al. Perinatal Outcomes After the Use of Kampo Medicines Containing Ephedra During Pregnancy. Pharmacoepidemiol Drug Saf. 2025 Nov;34(11):e70251.
URL：https://pubmed.ncbi.nlm.nih.gov/41184969/
