東北大学大学院医学系研究科・医学部

STAFF

Professor

• Sakurai, MikaAssoc. Prof. 櫻井 美佳 准教授
  

Other Faculty / Staff

• Yamamoto, Masayuki

  Professor M.D.,Ph.D. 山本 雅之 教授

• Suzuki, Yoichi

  Visiting Professor M.D.,Ph.D. 鈴木 洋一 客員教授

CONTACT

OUTLINE

This division engages in research activities that support genome cohort studies conducted by the Tohoku Medical Megabank Organization (ToMMo). We are involved in the education and training of personnel at ToMMo through an originally developed educational program (2016 BMC Med Edu). In addition, we developed a SNP array optimized for the Japanese population and efficiently generated large-scale genotyping data (2021 J Biochem). We are further aiming to implement these resources for practical application in disease risk prediction.
In our laboratory, we are also investigating the molecular mechanisms underlying allergic inflammatory diseases, with a particular focus on matrix metalloproteinases (MMPs) and a member of the water-soluble B vitamin group, biotin (2021 J Nutr Sci Vitaminol; 2024 Nutrients).

当分野は東北メディカル・メガバンク機構(ToMMo)のゲノムコホート研究を支える研究活動を行っています。ToMMoの事業に携わる様々な職種に対応するため、独自に開発した教育プログラムも活用して人材育成に取り組んでいます。また、日本人集団のゲノム解析に最適化したSNPアレイ開発と大規模データ収集を行うとともに、これらをゲノム情報にもとづく疾患リスク予測として社会実装することを目指しています。
さらに、マトリックスメタロプロテアーゼ(MMPs)や水溶性ビタミンB群に属するビオチンに着目して、アレルギー性炎症疾患の病態メカニズムの解明も進めています。

ARTICLE

Sakurai-Yageta M, et al. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. BMC Med Educ. 2019 Aug 2;19(1):297.
URL：https://doi.org/10.1186/s12909-019-1725-5

Sakurai-Yageta M, et al. Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs. J Biochem. 2021 May 13;mvab060.
URL：https://doi.org/10.1093/jb/mvab060

Sakurai-Yageta M, et al. Association between Serum Biotin Levels and Cedar Pollinosis in Japanese Schoolchildren. J Nutr Sci Vitaminol. 2021;67(4):211-216.
URL：https://doi.org/10.3177/jnsv.67.211

Sakurai-Yageta M, Suzuki Y. Molecular Mechanisms of Biotin in Modulating Inflammatory Diseases. Nutrients 2024 Jul 27;16(15):2444.
URL：https://doi.org/10.3390/nu16152444