東北大学大学院医学系研究科・医学部

STAFF

Professor

• Ishii, Naoto Professor. 石井 直人 教授
  

Other Faculty / Staff

• Kawabe, Takeshi

  Assoc. Prof. 河部 剛史 准教授

• Tayama, Shunichi

  Assistant Prof. 田山 舜一 助教

CONTACT

OUTLINE

The immune system is an extremely sophisticated biological system that discriminates between self and non-self and specifically memorizes non-self by a network of various immune cells. Our laboratory has been the first in the world to discover the common γ chain (γc, IL2RG) and T cell co-stimulatory molecules (gp34/OX40 ligands) that are essential for T cell development, differentiation, and proliferation, and thereby elucidate the regulatory mechanisms of T cell differentiation, proliferation, activation, and memory generation. Abnormalities in these regulatory mechanisms cause various immune diseases such as allergies, autoimmune diseases, and immunodeficiency diseases. In particular, the elucidation of the regulatory mechanisms of immunological memory will enable us to develop therapeutic strategies for allergy and autoimmune diseases such as rheumatoid arthritis, as well as ideal vaccines. Recently, we have also begun to study group 2 innate lymphocytes, which are involved in allergies, and memory-phenotype (MP) cells, which are attracting attention as a new T-cell population. Through these studies, we are expanding our research to contribute to the development of therapies and vaccines for immune diseases.

免疫系は、リンパ球を中心とした免疫細胞のネットワークにより自己・非自己を識別し、その情報を記憶する極めて高度な生命システムです。当研究室ではこれまでに、T細胞の発生・分化・増殖に必須なサイトカイン受容体（γc鎖）ならびにT細胞補助シグナル分子（gp34/OX40 リガンド）を世界に先駆けて単離し、T細胞の分化・増殖・活性化ならびに記憶の制御機構を分子レベルで解明してきました。これらの制御機構の異常はアレルギーをはじめ、自己免疫疾患や動脈硬化などの慢性炎症性疾患、免疫不全症などさまざまな免疫疾患を引き起こします。特に、免疫記憶の制御機構が解明できれば、アレルギーや関節リウマチなどの自己免疫疾患を治療法や理想的なワクチンの開発が可能になります。また、最近ではアレルギーに関わる2型自然リンパ球の研究や、新たなT細胞として注目されるmemory-phenotype（MP）細胞の研究も開始しました。これらの研究を通して、免疫疾患の治療法開発やワクチン開発に貢献できるよう研究活動を展開しています。

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  Our members
  研究室メンバー

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  Sharing each research progress at weekly meeting
  毎週のミーティングにて研究内容を共有

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  Student FIRST! Always give helping hand to you
  なんでも相談をできる風通しの良い環境

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  Eligible research advise for each person
  一人一人に対し、的確な研究指導

ARTICLE

Sato K, et al. Circulating memory-phenotype CD4+ T cells rapidly accumulate in the ischemic gut to exacerbate tissue injury in an innate manner. Cell Rep 45(8): 117745, 2026. doi: 10.1016/j.celrep.2026.117745.
URL： https://doi.org/10.1016/j.celrep.2026.117745

Tayama S, et al. Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation. Front Immunol 16: 1506580, 2025. doi: 10.3389/fimmu.2025.1506580.
URL： https://doi.org/10.3389/fimmu.2025.1506580

Yang Z, et al. Naturally Arising Memory-Phenotype CD4+ T Lymphocytes Give Rise to Multiple Helper Subsets to Contribute to Tumor Immunity while Inhibiting GVHD. Cancer Immunol Res 13(6): 897-911, 2025. doi: 10.1158/2326-6066.CIR-24-0598.
URL： https://doi.org/10.1158/2326-6066.CIR-24-0598

Kawajiri A, et al. Naturally arising memory-phenotype CD4+ T lymphocytes contain an undifferentiated population that can generate TH1, TH17, and Treg cells. Sci Adv 10(49): eadq6618, 2024. doi: 10.1126/sciadv.adq6618.
URL： https://doi.org/10.1126/sciadv.adq6618

Li J, et al. Excess generation and activation of naturally arising memory-phenotype CD4+ T lymphocytes are inhibited by regulatory T cells in steady state. Front Immunol 15: 1429954, 2024. doi: 10.3389/fimmu.2024.1429954.
URL： https://doi.org/10.3389/fimmu.2024.1429954

LINK

• 2025年度 医学部奨学賞・東北医学会奨学賞・医学部学生奨学賞授与式を行いました
• 医学部奨学賞・東北医学会奨学賞・医学部学生奨学賞授与式が行われました