東北大学大学院医学系研究科・医学部

STAFF

Professor

• Miura, YuichiroProfessor. 三浦 雄一郎 教授
  

CONTACT

OUTLINE

The aim of our laboratory is to clarify the factors that affect the child development through following cohort studies.

1. The Japan Environment and Children’s Study (JECS)
We participate in JECS and are responsible for the participants in the Miyagi area. JECS is an ongoing nationwide and government funded birth cohort. Approximately 100,000 expecting mothers were recruited in designated 15 areas between January 2011 and March 2014. The mothers and their children have been followed regularly since then. This birth cohort study is aimed at investigating the influence of environmental factors including chemical substances such as Per- and Polyfluoroalkyl Substances (PFAS), lead, mercury, and nicotine on the health and development of children.

2. Premature birth cohort
All infants who were born in the Miyagi prefecture and whose birth weight were < 1,250 g have been registered and regularly checked up their growth and development since 2005. Their gestational age, birth weight, and treatment histories have been recorded and accumulated. Using this database, we explore causal relationship between developmental disorder in later life and perinatal environmental factors including premature birth itself, several morbidities such as chronic lung disease and patent ductus arteriosus, and medical practice.

私たちの研究室では、以下のコホート研究を通してこどもの発達に影響を及ぼす要因を明らかにすることを目指しています。

1. エコチル調査
環境省が主導するエコチル調査という大規模出生コホート調査に参加し、宮城県内の調査を担当しています。この調査では、日本中の15の地域からおよそ100,000組のお母さんとお子さんに参加していただき、質問票への回答や身体計測値，血液・尿検査結果などのデータを集めています。この調査を通じて、有機フッ素化合物 (PFAS)、鉛、水銀、ニコチンなどの化学物質を含めたお子さんを取り巻く環境の様々な要因が、健康・発達に対してどのような影響を及ぼすのかを調べています。

2. さとめんこ事業
2005年以降、宮城県では1,250 g未満で出生した全てのお子さんに対して定期的に発育・発達のフォローアップを行っています。また妊娠週数や出生体重、新生児集中治療の内容も記録しています。このデータベースを用いて、早産出生そのもの、慢性肺疾患や動脈管開存症などの病態、さらにはそれらに対する医療行為など出生前後の環境因子が将来的な発達障害にどのように関連するかを調べています。

ARTICLE

Ono T, et al. Ductus Arteriosus of Extremely Preterm Twins is More Resistant to Cyclooxygenase Inhibitors Than Those of Singletons. Pediatr Cardiol 43(3):624-630,2022.
URL：https://doi.org/10.1007/s00246-021-02765-0

Sakurai Y, et al. Clinical and Bacteriologic Characteristics of Six Cases of Bifidobacterium breve Bacteremia Due to Probiotic Administration in the Neonatal Intensive Care Unit. Pediatr Infect Dis J 41(1):62-65,2022.
URL：https://doi.org/10.1097/INF.0000000000003232

Miura Y, et al. A parallelized pumpless artificial placenta system significantly prolonged survival time in a preterm lamb model. Artif Organs 40(5):E61-8,2016.
URL：https://doi.org/10.1111/aor.12656

Miura Y, et al. Maternal intravenous treatment with either azithromycin or solithromycin clears Ureaplasma parvum from the amniotic fluid in an ovine model of intrauterine infection. Antimicrob Agents Chemother 58(9):5413-20,2014.
URL：https://doi.org/10.1128/AAC.03187-14

Miura Y, et al. Novel modification of an artificial placenta: pumpless arteriovenous extracorporeal life support in a premature lamb model. Pediatr Res 72(5):490-4,2012.
URL：https://doi.org/10.1038/pr.2012.108