東北大学大学院医学系研究科・医学部

STAFF

Professor

• Kumada, KazukiProfessor. 熊田 和貴 教授
  

Other Faculty / Staff

• Kudo, Hisaaki

  Lect. 工藤 久智 講師

• Li, Bin

  Lect. 李 賓 講師

• Hasegawa, Atsushi

  Assistant Prof. 長谷川 敦史 助教

• He, Xiaodong

  Assistant Prof. 何 暁東 助教

CONTACT

OUTLINE

Department of Biobank Life Science, as one of the departments of Tohoku Medical Megabank Organization (ToMMo), is responsible for the development and management of the biobank facilities. Biobanks may be classified into two types by its design, either disease-oriented or population-based biobanks. Tohoku Medical Megabank Project (TMM) biobank is a large, advanced population-based biobank that stores and provides biological specimens such as plasma, serum, buffy coat, genomic DNA, urine, and mononuclear cells from peripheral or umbilical cord blood from participants of the TMM cohort studies together with the corresponding anonymized data, various tests, and analyses. Using modern technologies including automation system and information communication technologies we realize the accurate manipulation of the biological specimens. The TMM biobank have become an important resource in medical research, supporting many types of research like genomics and personalized medicine. Since high-quality research requires good-quality samples and information, we are conducting research such as optimization of the management of biological specimen and data in order to provide them in good-quality. We also study addressing whether preserved cell samples can be used for advanced functional analyses reflecting individual genomic polymorphisms and disease risks.

バイオバンク生命科学分野は東北メディカル・メガバンク機構に属し、バイオバンクの構築と管理に関わる研究を行います。バイオバンクには病院の試料を収集する病院型と、一般住民の試料を集める住民型があり、当機構のバイオバンクはメガバンク機構の住民健康調査（コホート研究）と連動した住民型の大型バイオバンクです。当バイオバンクでは、研究参加への同意が得られた提供者から血漿、血清、バフィーコート、ゲノムDNA 、尿、末梢血および臍帯血由来の単核球などの生体試料を、匿名化された健康情報と連結した形で収集・保存しており、自動システムや情報通信技術を駆使することにより、正確な試料の調整や保存の管理を実現しています。これらの試料や情報は、学内外を問わず多くの研究者に利用され、ゲノム情報に基づいた個別化医療・予防の推進に役立てられます。質の高い研究には良い品質の試料や情報が必要であり、私たちは、より良い品質の生体試料の提供するために、生体試料とデータの管理の最適化などの研究を行っています。また、保存された細胞などを用いて、各人の遺伝子多型と疾患リスクの関連の検証を目指した新たな実験系の開発に取り組みます。

ARTICLE

Sawahashi M, et al. Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis. Journal of Gastroenterology. e82291, 2025
URL：https://doi.org/10.1007/s00535-025-02263-7

Ohneda K, et al. Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan. Journal of Human Genetics. 70, 3, p. 147-157, 2025
URL：https://doi.org/10.1038/s10038-024-01314-w

Kudo H, et al. Detection and Correction of Sample Misidentifications in a Biobank Using the MassARRAY System and Genomic Information. Biopreservation and biobanking. 22: 373–382, 2024
URL：https://doi.org/10.1089/bio.2022.0211

Shiraishi K, et al. Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses. Cancer Communications. 44, 2, p. 287-293, 2024
URL：https://doi.org/10.1002/cac2.12498

Shindo N, et al. Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1. Cell Reports. 41, 9, 111723, 2022
URL：https://doi.org/10.1016/j.celrep.2022.111723