医科学専攻
- Master's Courses
修士課程 - Doctoral Courses
博士課程
Aging Research and Geriatric Medicine(Institute of Development, Aging and Cancer)臨床加齢医学研究(加齢医学研究所)
STAFF
Professor
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Taki, YasuyukiProfessor.M.D.Ph.D. 瀧 靖之 教授・医学博士 (兼任)
Other Faculty / Staff
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Nakase, Taizen
Assoc. Prof.Director of the clinic.M.D.Ph.D. 中瀬 泰然 准教授・診療科長・医学博士 (兼任) -
Tatewaki, Yasuko
Assistant Prof.Chief medical director.M.D.Ph.D. 舘脇 康子 助教・医局長・医学博士 (兼任)
CONTACT
TEL:+81-22-717-8556
E-MAIL:nmr_office*grp.tohoku.ac.jp
(「*」を「@」に変換してください)
OUTLINE
The Department of Aging Research and Geriatric Medicine is part of the Division of Brain Science at the Institute of Development, Aging and Cancer. The department also includes a clinical section affiliated with Tohoku University Hospital.
Our department is mainly engaged in brain imaging database research using magnetic resonance imaging (MRI) on a large number of healthy individuals. In particular, we are trying to understand how genetic and environmental factors, such as lifestyle, affect brain morphology, brain function, and cognition. For this purpose, we have collected brain MRIs from numerous subjects of various ages and created one of the world’s largest brain imaging databases, which combines data on lifestyle, cognition, and genes. We are using this database to analyze correlations between brain morphology, cerebral blood flow, cognition, and several influencing factors. Furthermore, we are researching AI-based image analysis, engaging in extensive industry-academia collaborative research, creating university-launched startup companies, and promoting social implementation activities.
加齢医学研究所では脳科学研究部門の一分野として、また、東北大学病院では加齢・老年病科としての診療科を持つ研究分野です。
臨床加齢医学研究分野では主に多数の健常人の磁気共鳴画像(MRI)を用いた脳画像データベース研究を行っています。
具体的には、生活習慣等の環境要因と遺伝要因が脳形態や脳機能、認知力にどのように影響するかを解明しています。それらを明らかにするために、幅広い年齢層の多数の被験者から脳MRIを収集し、生活習慣、認知力、遺伝子のデータを組み合わせた世界でも有数の規模の脳画像データベースを作成し、このデータベースを用いて、脳形態、脳血流、認知力と種々の要因との相関解析を行っています。更には、AIを用いた画像解析等の研究も遂行し、産学連携、大学発スタートアップ企業の創出等、社会実装の活動も非常に多く行っています。
Group photo of Laboratory members
研究室メンバー集合写真Dementia Clinical Conferences
認知症診療カンファレンスの様子Development of brain image analysis technology
脳画像解析技術の開発をしています。Construction of MRI image database
MRI画像データベースを構築しています。
ARTICLE
Bethlehem RAI, et al. Brain charts for the human lifespan. Nature. Apr;604(7906):525-533, 2022
URL:http://doi.org/doi: 10.1038/s41586-022-04554-y
Benjamin T, Taki Y. Learning a cortical parcellation of the brain robust to the MRI segmentation with convolutional neural networks. Med Image Anal. Apr:61:101639, 2020
URL:https://doi.org/10.1016/j.media.2020.101639
Benjamin T, et al. Segmentation of the hippocampus by transferring algorithmic knowledge for large cohort processing. Med Image Anal. Jan:43:214-228, . 2018
URL:https://doi.org/10.1016/j.media.2017.11.004
Nakase T, et al. Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease. Alzheimers Res Ther. Jan 13;15(1):15, 2023
URL:https://doi.org/10.1186/s13195-023-01165-1
Takeishi J, et al. Alzheimer's Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet. International Journal of Molecular Sciences. Nov 15;22(22):12310, 2021
URL:https://doi.org/10.3390/ijms222212310