医科学専攻
- Master's Courses
修士課程 - Doctoral Courses
博士課程
Division of Cancer Stem Cellがん医科学講座 / がん幹細胞学分（宮城県立がんセンター）
STAFF
Professor
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Keiichi, TamaiProfessor. 玉井恵一 教授
CONTACT
TEL：＋81-22-384-3151
E-MAIL：tamaikeiichi*med.tohoku.ac.jp
（「*」を「@」に変換してください）
OUTLINE
Successful treatment of advanced cancers is challenging, and limited therapeutic options are currently available, particularly for solid tumors. Our research focuses on the heterogeneity of cancer tissues, identification of cancer cells with particularly high malignant potential (cancer stem cells), and gaining deeper understanding of the pathogenesis of these tumors, all aimed at establishing novel cancer therapies. Our study primarily involves rare cancers such as head and neck cancer and cholangiocarcinoma, and we perform research while establishing and utilizing xenograft model mice.
Our department is an affiliated department established at the Miyagi Cancer Center Research Institute (Natori City). For our research, we also use clinical specimens obtained from the adjacent hospital.
進行がんを完治させることは大きな課題ですが、特に固形がんに対しては手段が限られているのが現状です。私たちはがん組織の不均一性に着目し、特に悪性度の高いがん細胞（≈がん幹細胞）を同定して、その病態を理解することで新しいがん治療法を確立することを目指しています。主に頭頸部癌・胆管癌などの希少癌に着目し、異種移植モデルマウスを樹立・活用しながら研究を行っています。
当分野は宮城県立がんセンター研究所（名取市）に設置された連携講座です。隣接する病院の臨床検体も活用しつつ、研究を進めています。
ARTICLE
Fujii K., et al. Establishment of a monoclonal antibody against glycosylated CD271 specific for cancer cells in immunohistochemistry, Cancer Sci. in press (2022).
URL：https://doi.org/10.1111/cas.15340
Tamai K., et al. Their Molecular Basis, and Therapeutic Implications (Review), Front Physiol. 12 824261 (2022). https://doi.org/10.3389/fphys.2021.824261.
Fukushi D., et al. BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma, Cancer Sci. 112 (2021) 4580–4592.
URL：https://doi.org/10.1111/cas.15115
Morita S., et al. Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells., Cancer Lett. 461 144–152 (2019).
URL：https://doi.org/10.1016/j.canlet.2019.07.011
M. Mochizuki, et al. CD271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma., Lab Invest. 99 (2019) 1349–1362.
URL：https://doi.org/10.1038/s41374-019-0246-5
