東北大学大学院医学系研究科・医学部

STAFF

Professor

• Kushimoto, ShigekiProfessor. 久志本 成樹 教授
  

Other Faculty / Staff

• Kudo, Daisuke

  Assoc. Prof. 工藤 大介 准教授

• Fujita, Motoo

  Assistant Prof. 藤田 基生 助教

CONTACT

OUTLINE

Our faculty continues to provide innovation and leadership across the spectrum of emergency medicine and critical care, from basic science to clinical trials, disaster medicine, and big data analysis using AI.
1) Clinical research
Real-World Evidence using database of multi-institutional observational study/ Real-World Data
A. Pathophysiological analysis and treatment of coagulation and fibrinolysis changes in acute stress condition
B. Metabolic resuscitation in patients with sepsis and severe trauma
2) Translational research
Biobank and Genetic Analysis in Emergency and Critical Care Medicine; From basic to clinical research on endothelial damage, especially focusing on endothelial glycocalyx
3) Big Data analysis
Novel diagnostic and therapeutic strategy for emergency and critically ill patients by AI analysis of Big Data from large clinical database

救急・集中治療領域における血管内皮から災害医療、AIを用いたビッグデータ解析までをテーマとしています。
１）臨床研究
多施設研究データおよびreal world dataに基づく臨床疫学 Real World Evidenceの発信
. 急性期凝固異常の病態解明と治療法開発
. 敗血症および外傷患者におけるmetabolic resuscitation
２）トランスレーショナルリサーチ
救急･集中治療領域におけるバイオバンクと遺伝子解析; グリコカリックス障害に注目した血管内皮細胞障害に関する臨床および基礎研究
3)ビッグデータ解析
大規模データベースを用いたAI解析による新たな診断・治療アプローチの開発

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  Hybrid ER with self-running CT and Interventional Angiography System
  CTと血管撮影装置を備えたハイブリッドER

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  Doctor helicopter to provide emergency care from the scene
  救急医療の臨床を支えるドクターヘリ

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  Clinical and Research members
  診療と研究を支えるスタッフ

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  Electron microscopic findings of the endothelial glycocalyx
  血管内皮グリコカリックスの超微形態

ARTICLE

Sato T, et al. Associations between low body mass index and mortality in patients with sepsis: A retrospective analysis of a cohort study in Japan. PLoS One. 2021 Jun 8;16(6):e0252955.

Sampei S, et al. Endothelial Glycocalyx Disorders May Be Associated With Extended Inflammation During Endotoxemia in a Diabetic Mouse Model. Front Cell Dev Biol. 2021 Apr 1;9:623582.

Kushimoto S, et al. Impact of blood glucose abnormalities on outcomes and disease severity in patients with severe sepsis: An analysis from a multicenter, prospective survey of severe sepsis. PLoS One. 2020 Mar 11;15(3):e0229919.

Kudo D, et al. Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies. Crit Care. 2021 Mar 19;25(1):114.

Kushimoto S, et al. Impact of Body Temperature Abnormalities on the Implementation of Sepsis Bundles and Outcomes in Patients With Severe Sepsis: A Retrospective Sub-Analysis of the Focused Outcome Research on Emergency Care for Acute Respiratory Distress Syndrome, Sepsis and Trauma Study. Crit Care Med. 2019 May;47(5):691-699.