東北大学大学院医学系研究科・医学部

STAFF

Professor

• Emi, KannoProfessor. 菅野　恵美 教授
  

Other Faculty / Staff

• Tanno, Hiromasa

  Lect. 丹野 寛大 講師

• Yuki, Sato

  Research Associate. 佐藤 佑樹 助手

CONTACT

OUTLINE

Our laboratory aims to develop evidence-based nursing practice for people with health support needs. In particular, we aim to develop best practices for the care of chronic ulcers, mucosal inflammation, and enterocolitis through the mechanisms of skin and mucosal tissue repair processes.

Our research interests are as follows:
1) Immunological mechanisms for delayed skin and mucosal healing processes
2) Involvement of C-type lectin receptors in the skin and mucosal healing processes
3) Novel therapies for patients with chronic wounds, such as diabetic foot ulcers, pressure ulcers, and radiation-induced ulcers

Based on our study findings, our laboratory will support researchers who will lead the field of nursing practice science.

看護の対象者に対して適切な日常生活援助を実践するためには、看護学のみならず幅広い学問・知識の統合が不可欠です。当分野では、最新の科学的根拠に基づく看護技術の開発を目指し、病態モデルを用いたエビデンスの構築を実施しています。現在、免疫学的手法を用いて、皮膚および粘膜治癒と炎症反応に注目した研究に主軸を置き、「皮膚・粘膜治癒過程における治癒遅延への免疫応答の関与」「難治性潰瘍に対する新規治療法の開発」等のテーマに取り組んでいます。さらに、放射線皮膚炎など疾患に対する治療の過程で生じる皮膚・粘膜領域の有害事象に対する新規ケア法の確立を目指し、他分野、大学病院と連携して研究を進めています。
これらの研究により得られた新知見より、QOLを高め、アンメットニーズを満たすことのできる看護技術を開発し、社会に実装できるよう展開してまいります。

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  Wound healing process is regulated by immune responses
  免疫による創傷治癒過程の制御

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  Distinct roles for Dectin-1 and Dectin-2 in wound healing
  創傷治癒におけるアクセル役・ブレーキ役

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  Photo of our laboratory
  分野風景

ARTICLE

Ishi S, et al. Cutaneous wound healing promoted by topical administration of heat-killed Lactobacillus plantarum KB131 and possible contribution of CARD9-mediated signaling. Sci Rep. 13(1):15917, 2023.
URL：https://doi.org/10.1038/s41598-023-42919-z

Shoji M, et al. CARD9-mediated macrophage responses and collagen fiber capsule formation caused by textured-type breast implants. Plast Reconstr Surg. Online ahead of print.
URL：https://doi.org/10.1097/PRS.0000000000011152

Yamaguchi K, et al. Distinct roles for Dectin-1 and Dectin-2 in skin wound healing and neutrophilic inflammatory responses. J Invest Dermatol. 141(1):164-176, 2021.
URL：https://doi.org/10.1016/j.jid.2020.04.030

Tanno H, et al. Topical administration of heat-killed Enterococcus faecalis strain KH2 promoted re-epithelialization and granulation tissue formation during skin wound-healing. Biomedicines, 9(11): 1520, 2021.
URL：https://doi.org/10.3390/biomedicines9111520

Miura T, et al. Dectin-2-Mediated Signaling Leads to Delayed Skin Wound Healing through Enhanced Neutrophilic Inflammatory Response and Neutrophil Extracellular Trap Formation. J Invest Dermatol. 139(3):702-711, 2019.
URL：https://doi.org/10.1016/j.jid.2018.10.015