東北大学大学院医学系研究科・医学部

STAFF

Professor

• Miyashita, MinoruProfessor. 宮下 穣 教授
  

Other Faculty / Staff

• Tada, Hiroshi

  Assistant Prof. 多田 寛 准教授

• Hamanaka, Yohei

  Assistant Prof. 濱中 洋平 准教授

• Harada, Narumi

  Assistant Prof. 原田 成美 助教

• Ebata, Akiko

  Assistant Prof. 江幡 明子 助教

• Sato, Mami

  Assistant Prof. 佐藤 真美 助教

• Sato, Miku

  Assistant Prof. 佐藤 未来 助教

CONTACT

OUTLINE

Our department conducts comprehensive surgical oncology research focusing on the breast, thyroid, and parathyroid glands. Our research encompasses a wide range of diseases, including breast cancer, other breast tumors, thyroid cancer, and functional disorders such as hyperthyroidism and hyperparathyroidism. We actively engage in diverse research approaches, from basic and clinical research to translational studies.
Key areas of our research include biological investigations into breast and thyroid cancers—such as endocrine regulation, tumor immunology, and cancer metabolism—as well as genomic analysis. We also conduct epidemiological studies in collaboration with the Tohoku Medical Megabank Organization, research on the individualization of breast cancer screening, and projects that integrate medical and engineering expertise. These efforts have resulted in numerous publications and presentations at academic conferences.
In addition, we are committed to utilizing both our original clinical datasets and publicly available clinical and genomic data to drive forward research and share findings both domestically and internationally.
Our department plays a leading role in cancer research in Japan, covering a broad spectrum of oncology, while also dedicating significant efforts to nurturing the next generation of researchers.

本分野では、乳腺、甲状腺、副甲状腺に関する外科腫瘍学の研究を行っています。対象疾患は乳癌をはじめ、その他の乳腺腫瘍、甲状腺癌、甲状腺・副甲状腺機能亢進症など多岐にわたり、基礎研究から臨床研究、トランスレーショナルリサーチまで幅広く取り組んでいます。
研究内容として、乳癌および甲状腺癌に関する生物学的研究（内分泌動態、腫瘍免疫、がん代謝など）やゲノム解析、東北メディカル・メガバンク機構との連携による疫学研究、乳がん検診の個別化に関する研究、医工学連携に基づく研究などがあり、これまでに数多くの成果を挙げ論文・学会にて発表をしてきました。また、独自の臨床データや公的な臨床・ゲノムデータを活用した研究も積極的に推進しており、国内外への情報発信を行っています。
本分野は、広い領域にわたって日本のがん研究をリードしており、同時に次世代の研究者育成にも力を注いでいます。

ARTICLE

1.Miyashita M, Bell JSK, Wenric S, et al. Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations. Breast Cancer Res. 2023 May 25;25(1):58.

2.Harada-Shoji N, Suzuki A, Ishida T, et al. Evaluation of Adjunctive Ultrasonography for Breast Cancer Detection Among Women Aged 40-49 Years With Varying Breast Density Undergoing Screening Mammography: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2021 Aug 2;4(8):e2121505.

3.Sato M, Harada-Shoji N, Toyohara T, et al. L-type amino acid transporter 1 is associated with chemoresistance in breast cancer via the promotion of amino acid metabolism. Sci Rep. 2021 Jan 12;11(1):589.

4.Ohuchi N, Suzuki A, Sobue T, et al. Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial. Lancet. 2016 Jan 23;387(10016):341-348.

5.Miyashita M, Sasano H, Tamaki K, et al. Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study. Breast Cancer Res. 2015 Sep 4;17(1):124.

LINK

• 腫瘍組織や血液のDNA損傷修復活性の測定法の開発 ー抗がん剤の有効性や遺伝性腫瘍の診断を可能にー
• 仙台放送「仙臺いろは」に医学系研究科長・医学部長/婦人科学分野 八重樫伸生教授、乳腺・内分泌外科学分野 石田孝宣教授のインタビュー動画が掲載
• 世界初・日本発：超音波検査による乳がん検診のランダム化比較試験(J−START) ‐若い女性への乳がん検診の標準化と普及へ向けて‐ 第2報