医科学専攻

  • Master's Courses 
    修士課程
  • Doctoral Courses 
    博士課程

Breast and Endocrine Surgical Oncology乳腺・内分泌外科学

  • 乳癌(Breast Cancer)
  • 甲状腺癌(Thyroid Cancer)
  • 乳腺内分泌外科腫瘍学(Breast and Endocrine Surgical Oncology)
  • 乳癌検診個別化(Personalized Breast Cancer Screening)
  • がんゲノム(Cancer Genomics)
  • 個別化集学的治療(Personalized Multidisciplinary Approach)

STAFF

Professor

  • Miyashita, MinoruProfessor. 宮下 穣 教授

Other Faculty / Staff

  • Tada, Hiroshi
    Assistant Prof. 多田 寛 准教授
  • Hamanaka, Yohei
    Assistant Prof. 濱中 洋平 准教授
  • Harada, Narumi
    Assistant Prof. 原田 成美 助教
  • Ebata, Akiko
    Assistant Prof. 江幡 明子 助教
  • Sato, Mami
    Assistant Prof. 佐藤 真美 助教
  • Sato, Miku
    Assistant Prof. 佐藤 未来 助教

CONTACT

TEL:+81-22-717-7214
E-MAIL:michiko.sasaki.e1*tohoku.ac.jp
(「*」を「@」に変換してください)

OUTLINE

Our department conducts comprehensive surgical oncology research focusing on the breast, thyroid, and parathyroid glands. Our research encompasses a wide range of diseases, including breast cancer, other breast tumors, thyroid cancer, and functional disorders such as hyperthyroidism and hyperparathyroidism. We actively engage in diverse research approaches, from basic and clinical research to translational studies.
Key areas of our research include biological investigations into breast and thyroid cancers—such as endocrine regulation, tumor immunology, and cancer metabolism—as well as genomic analysis. We also conduct epidemiological studies in collaboration with the Tohoku Medical Megabank Organization, research on the individualization of breast cancer screening, and projects that integrate medical and engineering expertise. These efforts have resulted in numerous publications and presentations at academic conferences.
In addition, we are committed to utilizing both our original clinical datasets and publicly available clinical and genomic data to drive forward research and share findings both domestically and internationally.
Our department plays a leading role in cancer research in Japan, covering a broad spectrum of oncology, while also dedicating significant efforts to nurturing the next generation of researchers.

本分野では、乳腺、甲状腺、副甲状腺に関する外科腫瘍学の研究を行っています。対象疾患は乳癌をはじめ、その他の乳腺腫瘍、甲状腺癌、甲状腺・副甲状腺機能亢進症など多岐にわたり、基礎研究から臨床研究、トランスレーショナルリサーチまで幅広く取り組んでいます。
研究内容として、乳癌および甲状腺癌に関する生物学的研究(内分泌動態、腫瘍免疫、がん代謝など)やゲノム解析、東北メディカル・メガバンク機構との連携による疫学研究、乳がん検診の個別化に関する研究、医工学連携に基づく研究などがあり、これまでに数多くの成果を挙げ論文・学会にて発表をしてきました。また、独自の臨床データや公的な臨床・ゲノムデータを活用した研究も積極的に推進しており、国内外への情報発信を行っています。
本分野は、広い領域にわたって日本のがん研究をリードしており、同時に次世代の研究者育成にも力を注いでいます。

ARTICLE

1.Miyashita M, Bell JSK, Wenric S, et al. Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations. Breast Cancer Res. 2023 May 25;25(1):58.

2.Harada-Shoji N, Suzuki A, Ishida T, et al. Evaluation of Adjunctive Ultrasonography for Breast Cancer Detection Among Women Aged 40-49 Years With Varying Breast Density Undergoing Screening Mammography: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2021 Aug 2;4(8):e2121505.

3.Sato M, Harada-Shoji N, Toyohara T, et al. L-type amino acid transporter 1 is associated with chemoresistance in breast cancer via the promotion of amino acid metabolism. Sci Rep. 2021 Jan 12;11(1):589.

4.Ohuchi N, Suzuki A, Sobue T, et al. Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial. Lancet. 2016 Jan 23;387(10016):341-348.

5.Miyashita M, Sasano H, Tamaki K, et al. Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study. Breast Cancer Res. 2015 Sep 4;17(1):124.

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