研究成果

  • ・Baba T, Kikuchi A, Hirayama K, Nishio Y, Hosokai Y, Kanno S, Hasegawa T, Sugeno N, Konno M, Suzuki K, Takahashi S, Fukuda H, Aoki M, Itoyama Y, Mori E, and Takeda A.
    Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson’s disease: a 3-year longitudinal study. Brain, in press.2012
  • ・Kano M, Mizuno T, Kawano Y, Aoki M, Kanazawa M, and Fukudo S.
    Serotonin transporter gene promoter polymorphism and alexithymia. Neuropsychobiology 65, 76-82.2012
  • ・Suzuki N, Aoki M, Mori-Yoshimura M, Hayashi YK, Nonaka I, and Nishino I.
    Increase in number of sporadic inclusion body myositis (sIBM) in Japan. J. Neurol. in press.2012
  • ・Suzuki N, Akiyama T, Takahashi T, Komuro H, Warita H, Tateyama M, Itoyama Y, and Aoki M.
    Continuous administration of poloxamer 188 reduces overload-induced muscular atrophy in dysferlin-deficient SJL mice. Neurosci. Res. in press.2012
  • ・Kanazawa M, Watanabe S, Tana C, Komuro H, Aoki M, and Fukudo S.
    Effect of 5-HT(4) receptor agonist mosapride citrate on rectosigmoid sensorimotor function in patients with irritable bowel syndrome. Neurogastroenterol. Motil. 23, 754-e332.2011
  • ・Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, and Aoki M.
    Review article: Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention. CYRIC Annual Report 2009.2011
  • ・Aoki M, Warita H, Mizuno H, Suzuki N, Yuki S, and Itoyama Y.
    Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger. Brain Res. 1382, 321-325.2011
  • ・Ito H, Fujita K, Nakamura M, Wate R, Kaneko S, Sasaki S, Yamane K, Suzuki N, Aoki M, Shibata N, Togashi S, Kawata A, Mochizuki Y, Mizutani T, Maruyama H, Hirano A, Takahashi R, Kawakami H, and Kusaka H.
    Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease. Acta Neuropathol. 121, 555-557.2011
  • ・Iida A, Takahashi A, Kubo M, Saito S, Hosono N, Ohnishi Y, Kiyotani K, Mushiroda T, Nakajima M, Ozaki K, Tanaka T, Tsunoda T, Oshima S, Sano M, Kamei T, Tokuda T, Aoki M, Hasegawa K, Mizoguchi K, Morita M, Takahashi Y, Katsuno M, Atsuta N, Watanabe H, Tanaka F, Kaji R, Nakano I, Kamatani N, Tsuji S, Sobue G, Nakamura Y, and Ikegawa S.
    A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese. Hum. Mol. Genet. 20, 3684-3692.2011
  • ・Izumi R, Suzuki N, Nagata M, Hasegawa T, Abe Y, Saito Y, Mochizuki H, Tateyama M, and Aoki M.
    A case of late onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency manifesting as recurrent rhabdomyolysis and acute renal failure. Intern. Med. 50, 2663-2668.2011
  • ・Kitamura K, Fujiyoshi K, Yamane J, Toyota F, Hikishima K, Nomura T, Funakoshi H, Nakamura T, Aoki M, Toyama Y, Okano H, and Nakamura M.
    Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury. PLoS ONE 6, e27706.2011
  • ・Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M, Miura E, Tanaka N, Tamai K, Furukawa K, Arai H, Mori F, Wakabayashi K, Aoki M, Itoyama Y, and Takeda A.
    The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein. PLoS ONE 6, e29460.2011
  • ・青木正志(Aoki M), 割田仁.
    29章 筋萎縮性側索硬化症（ALS）モデル. 完全版マウス・ラット疾患モデル活用ハンドブック 秋山徹,奥山隆平, 河府和義 編 羊土社, pp463-473.2011
  • ・Aoki M .
    筋萎縮性側索硬化症に対する治療法の開発. 保健医療科学 60, 125-129.2011
  • ・Aoki M .
    神経栄養因子による神経系の再構築. 脳21 14, 239-243.2011
  • ・Aoki M .
    東日本大震災の医療現場とその教訓. 難病と在宅ケア 日本プランニングセンター 17, 8-11.2011
  • ・青木正志(Aoki M), 加藤信介.
    ALS−SOD1の臨床と病理. Clinical Neuroscience 29, 1040-1043.2011
  • ・Aoki M .
    ALSに対する治療法開発の状況. 難病と在宅ケア 日本プランニングセンター 17 , 9-13.2011
  • ・浅田隆太, 青木正志(Aoki M).
    縁取り空胞を伴う遠位型ミオパチー患者におけるN-アセチルノイラミン酸の安全性および薬物動態の検討. 臨床評価 39, 238-243.2011
  • ・鈴木直輝, 青木正志(Aoki M).
    筋疾患update 封入体筋炎、Brain and Nerve 神経疾患の進歩. 医学書院 63, 1205-1215.2011
  • ・鈴木直輝, 青木正志(Aoki M).
    筋萎縮性側索硬化症とFUS/TLS. 日本臨床 69増刊 認知症学（下） pp.389-393.2011
  • ・Hadano S, Otomo A, Kunita R, Suzuki-Utsunomiya K, Akatsuka A, Koike M, Aoki M, Uchiyama Y, Itoyama Y, and Ikeda JE.
    Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking. PLoS One. 5, e9805.2010
  • ・Suzuki N, Aoki M, Warita H, Kato M, Mizuno H, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, and Itoyama Y.
    FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion. J. Hum. Genet. 55, 252–254.2010
  • ・Suzuki N, Takahashi T, Aoki M, Misu T, Konohana S, Okumura T, Takahashi H, Kameya S, Yamaki K, Kumagai T, Fujihara K, and Itoyama Y.
    Neuromyelitis optica preceded by hyperCKemia episode. Neurology 74, 1543-1545.2010
  • ・Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, and Kawakami H.
    Mutations of optineurin in amyotrophic lateral sclerosis. Nature 465, 223-226.2010
  • ・Kobayashi Z, Tsuchiya K, Arai T, Aoki M, Hasegawa M, Ishizu H, Akiyama H, and Mizusawa H.
    Occurrence of basophilic inclusions and FUS-immunoreactive neuronal and glial inclusions in a case of familial amyotrophic lateral sclerosis. J. Neurol. Sci. 293, 6-11.2010
  • ・Suzuki N, Mizuno H, Warita H, Takeda S, Itoyama Y, and Aoki M.
    Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis. J. Neurol. Sci. 294, 95-101.2010
  • ・Sanagi T, Yuasa S, Nakamura Y, Suzuki E, Aoki M, Warita H, Itoyama Y, Uchino S, Kohsaka S, and Ohsawa K.
    Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis. J. Neurosci. Res. 88, 2736-2746.2010
  • ・Katsuno M, Banno H, Suzuki K, Takeuchi Y, Kawashima K, Yabe I, Sasaki H, Aoki M, Morita M, Nakano I, Kanai K, Ito S, Ishikawa K, Mizusawa H, Yamamoto T, Tsuji S, Hasegawa K, Shimohata T, Nishizawa M, Miyajima H, Kanda F, Watanabe Y, Nakashima K, Tsujino A, Yamashita T, Uchino M, Fujimoto Y, Tanaka F, and Sobue G.
    Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 9, 875-884.2010
  • ・Shimazawa M, Tanaka H, Ito Y, Morimoto N, Tsuruma K, Kadokura M, Tamura S, Inoue T, Yamada M, Takahashi H, Warita H, Aoki M, and Hara H.
    An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS. PLoS ONE 5, e15307.2010
  • ・Hayashi S, Ohsawa Y, Takahashi T, Suzuki N, Okada T, Rikimaru M, Murakami T, Aoki M, and Sunada Y.
    Rapid screening for Japanese dysferlinopathy by fluorescent primer extension. Intern. Med. 49, 2693-2696.2010
  • ・Aoki M .
    運動ニューロン疾患の分類と診断・治療. からだの科学265　神経内科の病気のすべて 鈴木則宏 編 日本評論社, pp108-11.2010
  • ・Aoki M .
    神経難病の新展開　筋萎縮性側索硬化症. Bio Clinica 25, 48-53.2010
  • ・青木正志(Aoki M), 割田仁, 船越洋, 北村和也, 中村雅也, 岡野栄之.
    肝細胞増殖因子を用いた中枢神経再生　―筋萎縮性側索硬化症および脊髄損傷―. 脊椎脊髄ジャーナル 23, 867-75.2010
  • ・Aoki M .
    筋萎縮性側索硬化症のHGF治療. Clinical Neuroscience 28, 1312-1314.2010
  • ・青木正志(Aoki M), 割田仁, 糸山泰人.
    ALSに対するヒト型組み換えHGF蛋白を用いた第１相試験（治験）. JALSA 日本ALS協会 82, 10-12.2010
  • ・Endo K, Suzuki N, Ikenishi T, Aoki M, and Itoyama Y.
    Intravenous immunoglobulin treatment successfully improved subacute progressive polyradiculoneuropathy with polyclonal gammopathy. Intern Med. 48(23):2037-9.2009.PMID: 19952488
  • ・Nishiyama S, Ito T, Misu T, Takahashi T, Kikuchi A, Suzuki N, Jin K, Aoki M, Fujihara K, and Itoyama Y.
    A case of NMO seropositive for aquaporin-4 antibody more than 10 years before onset. Neurology 72, 1960-1961.2009.PMID: 19487655
  • ・Endo K, Suzuki N, Misu T, Aoki M, and Itoyama Y.
    Dorsal-roots enhancement and Wallerian degeneration of dorsal cord in the patient of acute sensory ataxic neuropathy. J Neurol. 256(10):1765-6.2009.PMID: 19479165
  • ・Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, and Aoki M.
    Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention. Neuroimage 47, 946-951.2009.PMID: 19426812
  • ・Sasaki S, Aoki M, Nagai M, Kobayashi M, and Itoyama Y.
    Mitochondrial alterations in transgenic mice with an H46R mutant Cu/Zn superoxide dismutase gene. J Neuropathol Exp Neurol. 68(4):365-73.2009.PMID: 19287315
  • ・Ono H, Suzuki N, Mizuno H, Tateyama M, Aoki M, and Itoyama Y.
    Elevated serum aldolase activity in a patient of non-eosinophilic myofasciitis and synovitis with perifascicular atrophy. Rinsho Shinkeigaku 49, 119-122.2009.PMID: 19348178
  • ・Suzuki N, Mizuno H, Nezu M, Takai Y, Misu T, Kuroda H, Aoki M, Nakashima I, and Itoyama Y.
    Procalcitonin might help in discrimination between meningeal neuro-Behcet disease and bacterial meningitis. Neurology 72, 762-763.2009.PMID: 19237707
  • ・Takahashi Y, Seki N, Ishiura H, Mitsui J, Matsukawa T, Kishino A, Onodera O, Aoki M, Shimozawa N, Murayama S, Itoyama Y, Suzuki Y, Sobue G, Nishizawa M, Goto J , and Tsuji S.
    Development of a high-throughput microarray-based resequencing system for neurological disorders and its application to molecular genetics of amyotrophic lateral sclerosis. Archives of Neurology, 65:1326-1332.2008.PMID: 18852346
  • ・Netsu M, Suzuki N, Mizuno H, Takai Y, Misu T, Aoki M, Nakajima I , and Itoyama Y.
    細性髄膜炎との鑑別を要した神経ベーチェット病の1例. 臨床神経学, 48:750-753. 2008
  • ・Mizuno H, Warita H, Aoki M, and Itoyama Y.
    Accumulation of chondroitin sulfate proteoglycans in the micro environment of spinal motor neurons in amyotrophic lateral sclerosis transgenic rats. Journal of Neuroscience Research, 86:2512-2523.2008.PMID: 18438943
  • ・Dagvajantsan B, Aoki M, Warita H, Suzuki N, and Itoyama Y.
    Up-regulation of insulin-like growth factor-II receptor in reactive astrocytes in the spinal cord of amyotrophic lateral sclerosis transgenic rats. Tohoku J Exp Med, 214:303-310.2008.PMID: 18441505
  • ・Tanaka K, Okada Y, Kanno T, Otomo A, Yanagisawa Y, Shouguchi-Miyata J, Suga E, Kohiki E, Onoe K, Osuga H, Aoki M, Hadano S, Itoyama Y, and Ikeda JE.
    A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice. Experimental Neurology, 211:378-386.2008.PMID: 18423451
  • ・Kato K, Suzuki N, Aoki M, Warita H, Jin K, and Itoyama Y.
    長期人工呼吸管理下に気管腕頭動脈瘻からの急性出血で死亡した家族性ALSの1例. 臨床神経学, 48:60-62.2008
  • ・Aoki M, Kiyonari H Nakamura H, and Okamoto H.
    R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development. Dev Growth Differ, 50:85-95.2008.PMID: 18067586
  • ・Ishigaki A, Aoki M, Nagai M, Warita H, Kato S, Kato M, Nakamura T, Funakoshi H, and Itoyama Y.
    Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model J Neuropathol Exp Neurol. 2007 Nov;66(11):1037-44.
Copyright © Tohoku Univ. All Rights Reserved.