東北大学大学院医学系研究科・医学部

STAFF

Professor

• Hasegawa, Takafumi Professor.M.D. Ph.D. 長谷川 隆文 教授
  

Other Faculty / Staff

• Baba, Toru

  Assoc. Prof.M.D. Ph.D. 馬場 徹 准教授

CONTACT

OUTLINE

Our department is dedicated to advancing research on the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease, and to promoting clinical research at the intersection of cognitive decline and musculoskeletal disorders.
Our work is organized around three pillars: (1) basic research to elucidate the mechanisms underlying dementia and motor dysfunction; (2) clinical research on early diagnosis and early intervention; and (3) training of the next generation of medical specialists in these fields. Our ultimate goal is to establish individualized, optimized care programs tailored to the specific characteristics of older adults with cognitive and motor impairments.
Recent investigations have employed nuclear medicine imaging to identify distinct subtypes of Parkinson's disease and to clarify the prognostic significance of cardiac sympathetic denervation. These studies exemplify our commitment to translational, interdisciplinary research bridging neurology, geriatric medicine, and rehabilitation.
Through collaboration across disciplines, we strive to build an advanced research center that improves quality of life for patients living with cognitive and motor disorders.

本講座では、アルツハイマー病・レビー小体型認知症・パーキンソン病をはじめとする神経変性認知症疾患の病態解明研究と、認知症・運動器疾患の融合領域における臨床研究を推進することを目的としています。基礎研究、早期診断・早期介入に関する臨床研究、および優秀な医療人材の育成という三つの柱を軸に、認知・運動機能障害を持つ高齢者の特性に合わせた最適化された個別化医療プログラムの確立を目指しています。核医学イメージングを用いたパーキンソン病の病型分類や、心臓交感神経障害の予後的意義の解明など、脳神経内科・老年医学・リハビリテーション医学の学際的連携のもとで研究を進めています。

ARTICLE

Sugimura Y, et al. Temporal patterns of motor and nonmotor symptom emergence in Parkinson's disease: a cluster analysis. Clin Parkinsonism Relat Disord. 100423, 2026.
URL： https://doi.org/10.1016/j.prdoa.2026.100423

Sugimura Y, et al. Neuroanatomical Correlate of Memory Impairment in Parkinson's Disease Assessed by Composite Recall and Recognition Test with MMSE. Dement Geriatr Cogn Disord. 2025.
URL： https://doi.org/10.1159/000548180

Nakamura T, et al. System-wise balance evaluation and its association with structural brain changes in Parkinson's disease. Clin Neurol Neurosurg. 257:109040, 2025.
URL： https://doi.org/10.1016/j.clineuro.2025.109040

Totsune T, et al. The heart of the matter: cardiac denervation casts doubt on the brain-first versus body-first hypothesis of Parkinson's disease. Mov Disord. 40(5):807-812, 2025.
URL： https://pubmed.ncbi.nlm.nih.gov/40099489/

Totsune T, et al. Nuclear imaging data-driven classification of Parkinson's disease. Mov Disord. 38(11):2053-2063, 2023.
URL： https://pubmed.ncbi.nlm.nih.gov/37638533/

LINK

• パーキンソン病の認知症予防への第一歩 認知症症状緩和とQOL改善へのドネペシルの効果
• 心臓自律神経障害がパーキンソン病の予後と関連　-MIBG心筋シンチグラフィー検査の新たな意義-