医科学専攻
- Master's Courses
修士課程 - Doctoral Courses
博士課程
Molecular Epidemiology(Environment and Genome Research Center)分子疫学(環境遺伝医学総合研究センター)
STAFF
Professor
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Kuriyama, ShinichiProfessor. 栗山 進一 教授 (兼任)
Other Faculty / Staff
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Obara, Taku
Assoc. Prof. 小原 拓 准教授 -
Orui, Masatsugu
Assoc. Prof. 大類 真嗣 准教授 -
Ishikuro, Mami
Lect. 石黒 真美 講師 -
Noda, Aoi
Assistant Prof. 野田 あおい 助教
CONTACT
TEL:+81-22-717-8104
E-MAIL:tommo-sansedai-secretary*grp.tohoku.ac.jp
(「*」を「@」に変換してください)
OUTLINE
Molecular epidemiology is a new interdisciplinary field in which genomic medicine and artificial intelligence technologies are combined with the foundation provided by epidemiology. We aim to unravel the interaction between genetics and the environment by utilizing genomic and omics information and applying artificial intelligence analysis technologies while using epidemiological methods. Our goal is to use these molecular epidemiological methods to recover missing heritability and to overcome multifactorial diseases, which have been a challenge for the world for many years. A disease derived from one disease concept may in fact be composed of many subgroups, each of which could have their own diverse cause and therapeutic effects. Therefore, multifactorial diseases may actually be multi-disease diseases.
分子疫学は疫学を基礎としそこにゲノム医学や人工知能解析技術などが融合した新たな学際的領域です。疫学手法を用いながら、ゲノム情報やオミックス情報を人工知能解析技術などを駆使して、遺伝・環境相互作用の解明を目指します。この分子疫学的手法を用いて、自閉スペクトラム症をはじめとする多因子疾患の病態を解明し、失われた遺伝率の回復とともに、これまで永年にわたっててこずってきた多因子疾患の克服を目指します。疾患によってはひとつの疾患概念でくくっていたものが実は多くのサブグループからなり、それぞれ原因や治療効果が異なっている可能性があります。多因子疾患は実は多病気疾患であるのかもしれないと考えています。
Laboratory members
研究室員集合写真Seminar
セミナー風景
ARTICLE
Kuriyama S, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. Int J Epidemiol. 49(1):18-19m, 2020. doi: 10.1093/ije/dyz169.
Ishikuro M, et al. Families' Health after the Great East Japan Earthquake: Findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Tohoku J Exp Med. 256(2): 93-101, 2022. doi: 10.1620/tjem.256.93.
Noda A, et al. Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Eur J Clin Pharmacol. 80 (8): 1171-1180, 2024. doi:10.1007/s00228-024-03685-7
Takahashi I, et al. Genome-wide association study based on clustering by obesity-related variables uncovers a genetic architecture of obesity in the Japanese and the UK populations. Heliyon. 10 (16): e36023, 2024. doi:10.1016/j.heliyon.2024.e36023
Usuzaki T, et al. Child-parent associations of hematocrit in trios of Japanese adulthood confirmed by the random family method: The TMM BirThree Cohort Study. Sci Rep. 14 (1): 19047, 2024. doi:10.1038/s41598-024-69752-2