研究成果

  • ・Baba T, Kikuchi A, Hirayama K, Nishio Y, Hosokai Y, Kanno S, Hasegawa T, Sugeno N, Konno M, Suzuki K, Takahashi S, Fukuda H, Aoki M, Itoyama Y, Mori E, and Takeda A.
    Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson’s disease: a 3-year longitudinal study. Brain, in press.2012
  • ・Suzuki N, Akiyama T, Takahashi T, Komuro H, Warita H, Tateyama M, Itoyama Y, and Aoki M.
    Continuous administration of poloxamer 188 reduces overload-induced muscular atrophy in dysferlin-deficient SJL mice. Neurosci. Res. in press.2012
  • ・Baba T, Takeda A, Kikuchi A, Nishio Y, Hosokai Y, Hirayama K, Hasegawa T, Sugeno N, Suzuki K, Mori E, Takahashi S, Fukuda H, and Itoyama Y.
    Association of olfactory dysfunction and brain metabolism in Parkinson’sdisease. Mov. Disord. 26, 621-628.2011
  • ・Ishioka T, Hirayama K, Hosokai Y, Takeda A, Suzuki K, Nishio Y, Sawada Y, Takahashi S, Fukuda H, Itoyama Y, and Mori E.
    Illusory misidentifications and cortical hypometabolism in Parkinson's disease. Mov. Disord. 26, 837-843.2011
  • ・Kanno S, Abe N, Saito M, Takagi M, Nishio Y, Hayashi A, Uchiyama M, Hanaki R, Kikuchi H, Hiraoka K, Yamasaki H, Iizuka O, Takeda A, Itoyama Y, Takahashi S, , and Mori E.
    White matter involvement in idiopathic normal pressure hydrocephalus: A voxel-based diffusion tensor imaging study. J. Neurol. 258, 1949-1957.2011
  • ・Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, and Aoki M.
    Review article: Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention. CYRIC Annual Report 2009.2011
  • ・Aoki M, Warita H, Mizuno H, Suzuki N, Yuki S, and Itoyama Y.
    Feasibility study for functional test battery of SOD transgenic rat (H46R) and evaluation of edaravone, a free radical scavenger. Brain Res. 1382, 321-325.2011
  • ・Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M, Miura E, Tanaka N, Tamai K, Furukawa K, Arai H, Mori F, Wakabayashi K, Aoki M, Itoyama Y, and Takeda A.
    The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein. PLoS ONE 6, e29460.2011
  • ・Takeda A, Saito N, Baba T, Kikuchi A, Sugeno N, Kobayashi M, Hasegawa T, and Itoyama Y.
    Functional imaging studies of hyposmia in Parkinson's disease. J Neurol Sci.289, 36-39. 2009.PMID: 19720385
  • ・Nishio Y, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Suzuki K, Itoyama Y, Takahashi S, and Mori E.
    Corticolimbic gray matter loss in Parkinson's disease without dementia. Eur. J. Neurol. 17, 1090-1097.2010
  • ・Hadano S, Otomo A, Kunita R, Suzuki-Utsunomiya K, Akatsuka A, Koike M, Aoki M, Uchiyama Y, Itoyama Y, and Ikeda JE.
    Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking. PLoS One. 5, e9805.2010
  • ・Okamura N, Shiga Y, Furumoto S, Tashiro M, Tsuboi Y, Furukawa K, Yanai K, Iwata R, Arai H, Kudo Y, Itoyama Y, and Doh-Ura K.
    In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET. Eur. J. Nucl. Med. Mol. Imag. 37, 934-941.2010
  • ・Suzuki N, Aoki M, Warita H, Kato M, Mizuno H, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, and Itoyama Y.
    FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion. J. Hum. Genet. 55, 252–254.2010
  • ・Suzuki N, Takahashi T, Aoki M, Misu T, Konohana S, Okumura T, Takahashi H, Kameya S, Yamaki K, Kumagai T, Fujihara K, and Itoyama Y.
    Neuromyelitis optica preceded by hyperCKemia episode. Neurology 74, 1543-1545.2010
  • ・Suzuki N, Mizuno H, Warita H, Takeda S, Itoyama Y, and Aoki M.
    Neuronal NOS is dislocated during muscle atrophy in amyotrophic lateral sclerosis. J. Neurol. Sci. 294, 95-101.2010
  • ・Sanagi T, Yuasa S, Nakamura Y, Suzuki E, Aoki M, Warita H, Itoyama Y, Uchino S, Kohsaka S, and Ohsawa K.
    Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis. J. Neurosci. Res. 88, 2736-2746.2010
  • ・Endo K, Suzuki N, Ikenishi T, Aoki M, and Itoyama Y.
    Intravenous immunoglobulin treatment successfully improved subacute progressive polyradiculoneuropathy with polyclonal gammopathy. Intern Med. 48(23):2037-9.2009.PMID: 19952488
  • ・Bradl M, Misu T, Takahashi T, Watanabe M, Mader S, Reindl M, Adzemovic M, Bauer J, Berger T, Fujihara K, Itoyama Y, and Lassmann H.
    Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo. Ann Neurol.Nov;66(5):630-43.2009.PMID: 19937948
  • ・Iwata T, Suzuki N, Mizuno H, Nakashima I, Kanbayashi T, and Itoyama Y.
    A marked decrease of orexin in the cerebrospinal fluid in a patient with myotonic dystrophy type 1 showing an excessive daytime sleepiness. Rinsho Shinkeigaku 49, 437-439.2009.PMID: 19715174
  • ・Petzold A, Brettschneider J, Jin K, Keir G, Murray NM, Hirsch NP, Itoyama Y, Reilly MM, Takeda A, and Tumani H.
    CSF protein biomarkers for proximal axonal damage improve prognostic accuracy in the acute phase of Guillain-Barré syndrome. Muscle Nerve. Jul;40(1):42-9.2009.PMID:19533642
  • ・Nishiyama S, Ito T, Misu T, Takahashi T, Kikuchi A, Suzuki N, Jin K, Aoki M, Fujihara K, and Itoyama Y.
    A case of NMO seropositive for aquaporin-4 antibody more than 10 years before onset. Neurology 72, 1960-1961.2009.PMID: 19487655
  • ・Endo K, Suzuki N, Misu T, Aoki M, and Itoyama Y.
    Dorsal-roots enhancement and Wallerian degeneration of dorsal cord in the patient of acute sensory ataxic neuropathy. J Neurol. 256(10):1765-6.2009.PMID: 19479165
  • ・Ishizu T, Kira J, Osoegawa M, Fukazawa T, Kikuchi S, Fujihara K, Matsui M, Kohriyama T, Sobue G, Yamamura T, Itoyama Y, Saida T, Sakata K, and Research Committee of Neuroimmunological Diseases.
    Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey. J Neurol Sci. May 15;280(1-2):22-8.2009.PMID: 19201428
  • ・Nakamura M, Misu T, Fujihara K, Miyazawa I, Nakashima I, Takahashi T, Watanabe S, and Itoyama Y.
    Occurrence of acute large and edematous callosal lesions in neuromyelitis optica. Mult Scler 15, 695-700.2009.PMID: 19435750
  • ・Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, and Aoki M.
    Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention. Neuroimage 47, 946-951.2009.PMID: 19426812
  • ・Misu T, Takano R, Fujihara K, Takahashi T, Sato S, and Itoyama Y.
    Marked increase in cerebrospinal fluid glial fibrillar acidic protein in neuromyelitis optica: an astrocytic damage marker. J Neurol Neurosurg Psychiatry 80, 575-577.2009.PMID: 19372295
  • ・Hosokai Y, Nishio Y, Hirayama K, Takeda A, Ishioka T, Sawada Y, Suzuki K, Itoyama Y, Takahashi S, Fukuda H, and Mori E.
    Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment. Mov Disord 24, 854-862.2009.PMID: 19199357
  • ・Tateyama M, Fujihara K, Misu T, and Itoyama Y.
    CCR7+ myeloid dendritic cells together with CCR7+ T cells and CCR7+ macrophages invade CCL19+ nonnecrotic muscle fibers in inclusion body myositis. J Neurol Sci 279, 47-52.2009.PMID: 19171354
  • ・Sasaki S, Aoki M, Nagai M, Kobayashi M, and Itoyama Y.
    Mitochondrial alterations in transgenic mice with an H46R mutant Cu/Zn superoxide dismutase gene. J Neuropathol Exp Neurol. 68(4):365-73.2009.PMID: 19287315
  • ・Abe N, Fujii T, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Nishio Y, Suzuki K, Itoyama Y, Takahashi S, Fukuda H, and Mori E.
    Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behaviour. Brain 132, 1386-1395.2009.PMID: 19339257
  • ・Ono H, Suzuki N, Mizuno H, Tateyama M, Aoki M, and Itoyama Y.
    Elevated serum aldolase activity in a patient of non-eosinophilic myofasciitis and synovitis with perifascicular atrophy. Rinsho Shinkeigaku 49, 119-122.2009.PMID: 19348178
  • ・Baba T, Nakashima I, Kanbayashi T, Konno M, Takahashi T, Fujihara K, Misu T, Takeda A, Shiga Y, Ogawa H, and Itoyama Y.
    Narcolepsy as an initial manifestation of neuromyelitis optica with anti-aquaporin-4 antibody. J Neurol. 2009 Feb;256(2):287-8.PMID: 19266146
  • ・Kamei S, Taira N, Ishihara M, Sekizawa T, Morita A, Miki K, Shiota H, Kanno A, Suzuki Y, Mizutani T, Itoyama Y, Morishima T, and Hirayanagi K.
    Prognostic value of cerebrospinal fluid cytokine changes in herpes simplex virus encephalitis. Cytokine. May;46(2):187-93.2009.PMID: 19261488
  • ・Misu T, Takahashi T, Nakashima I, Fujihara K, and Itoyama Y.
    Neuromyelitis optica and anti-aquaporin 4 antibody--distinct from multiple sclerosis. Rinsho Byori 57, 262-270.2009.PMID: 19363997
  • ・Suzuki N, Mizuno H, Nezu M, Takai Y, Misu T, Kuroda H, Aoki M, Nakashima I, and Itoyama Y.
    Procalcitonin might help in discrimination between meningeal neuro-Behcet disease and bacterial meningitis. Neurology 72, 762-763.2009.PMID: 19237707
  • ・Osoegawa M, Kira J, Fukazawa T, Fujihara K, Kikuchi S, Matsui M, Kohriyama T, Sobue G, Yamamura T, Itoyama Y, Saida T, Sakata K, Ochi H, Matsuoka T , and Research Committee of Neuroimmunological Diseases.
    Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: nationwide survey results over 30 years. Mult Scler,15(2):159-73.2009.
  • ・小野紘彦, 鈴木直輝, 水野秀紀, 竪山真規, 青木正志, 糸山泰人(Itoyama Y).
    血清 aldolase 値の上昇がみられた perifascicular atrophy をともなう非好酸球性筋膜滑膜炎の1例. 臨床神経 49, 119-122.2009
  • ・岩田朋晃, 鈴木直輝, 水野秀紀, 中島一郎, 神林 崇, 糸山泰人(Itoyama Y).
    髄液オレキシンが異常低値で重度の過眠症を呈した筋強直性ジストロフィーの1例. 臨床神経 49, 437-439.2009
  • ・三須建郎, 高橋利幸, 中島一郎, 藤原一男, 糸山泰人(Itoyama Y).
    視神経脊髄炎とアクアポリン4抗体 : 多発性硬化症との相違. 臨床病理 57, 262-270.2009
  • ・Osoegawa M, Kira J, Fukazawa T, Fujihara K, Kikuchi S, Matsui M, Kohriyama T, Sobue G, Yamamura T, Itoyama Y, Saida T, Sakata K, Ochi H, and Matsuoka T.
    Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: nationwide survey results over 30 years. Mult Scler, 5.2008.PMID: 18987106
  • ・Takahashi Y, Seki N, Ishiura H, Mitsui J, Matsukawa T, Kishino A, Onodera O, Aoki M, Shimozawa N, Murayama S, Itoyama Y, Suzuki Y, Sobue G, Nishizawa M, Goto J , and Tsuji S.
    Development of a high-throughput microarray-based resequencing system for neurological disorders and its application to molecular genetics of amyotrophic lateral sclerosis. Archives of Neurology, 65:1326-1332.2008.PMID: 18852346
  • ・Netsu M, Suzuki N, Mizuno H, Takai Y, Misu T, Aoki M, Nakajima I , and Itoyama Y.
    細性髄膜炎との鑑別を要した神経ベーチェット病の1例. 臨床神経学, 48:750-753. 2008
  • ・Okada Y, Matsumoto A, Shimazaki T, Enoki R, Koizumi A, Ishii S, Itoyama Y, Sobue G, and Okano H.
    Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells. Stem Cells, 26(12):3086-98.2008.PMID: 18757299
  • ・Mizuno H, Warita H, Aoki M, and Itoyama Y.
    Accumulation of chondroitin sulfate proteoglycans in the micro environment of spinal motor neurons in amyotrophic lateral sclerosis transgenic rats. Journal of Neuroscience Research, 86:2512-2523.2008.PMID: 18438943
  • ・Sasaki　H, Arimura K, Itoyama Y, Kwak S, Kira J, Nakashima K, Amano T, Inoue K, Uozumi T, Kohara N, Tsuji S, Tamagawa A, Toyoshima I, Mizutani T, Yoshii F, Sobue G , and Shimizu T.
    日本神経学会卒前教育小委員会(2008)モデル教育コア・カリキュラムおよび卒前教育における神経内科の現状に関するアンケート全国調査. 臨床神経学, 48(8):556-62.2008
  • ・Misu T, Fujihara K, and Itoyama Y.
    視神経脊髄炎（NMO）とアクアポリン4抗体. Brain Nerve, 60:527-537.2008
  • ・Takahashi T, Miyazawa I, Misu T, Takano R, Nakashima I, Fujihara K, Tobita M , and Itoyama Y.
    Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations. J Neurol Neurosurg Psychiatry, 79:1075-1078.2008.PMID: 18420727
  • ・Dagvajantsan B, Aoki M, Warita H, Suzuki N, and Itoyama Y.
    Up-regulation of insulin-like growth factor-II receptor in reactive astrocytes in the spinal cord of amyotrophic lateral sclerosis transgenic rats. Tohoku J Exp Med, 214:303-310.2008.PMID: 18441505
  • ・Inoue J, Ueno Y, Kogure T, Nagasaki F, Kimura O, Obara N, Kido O, Nakagome Y, Kakazu E, Matsuda Y, Fukushima K, Segawa H, Nakajima I, Itoyama Y, Takahashi M, Okamoto H , and Shimosegawa T.
    Analysis of the full-length genome of hepatitis B virus in the serum and cerebrospinal fluid of a patient with acute hepatitis B and transverse myelitis. J Clin Virol, 41:301-304.2008.PMID: 18291715
  • ・Tanaka K, Okada Y, Kanno T, Otomo A, Yanagisawa Y, Shouguchi-Miyata J, Suga E, Kohiki E, Onoe K, Osuga H, Aoki M, Hadano S, Itoyama Y, and Ikeda JE.
    A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice. Experimental Neurology, 211:378-386.2008.PMID: 18423451
  • ・Takano R, Misu T, Takahashi T, Izumiyama M, Fujihara K , and Itoyama Y.
    A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica. Tohoku J Exp Med, 215:55-59.2008.PMID: 18509235
  • ・Nakamura M, Miyazawa I, Fujihara K, Nakashima I, Misu T, Watanabe S, Takahashi T, and Itoyama Y.
    Preferential spinal central gray matter involvement in neuromyelitis optica : An MRI study. J Neurol. 255, 163-170. 2008 Feb 4
  • ・Kato K, Suzuki N, Aoki M, Warita H, Jin K, and Itoyama Y.
    長期人工呼吸管理下に気管腕頭動脈瘻からの急性出血で死亡した家族性ALSの1例. 臨床神経学, 48:60-62.2008
  • ・Itoyama Y .
    変わりつつある疾患の概念−視神経脊髄型多発性硬化症(OSMS)と視神経脊髄炎(NMO). 神経, 238-245. 2008
  • ・Sugeno N, Takeda A, Hasegawa T, Kobayashi M, Kikuchi A, Mori F, Wakabayashi K , and Itoyama Y.
    Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death. J Biol Chem, 283:23179-23188.2008.PMID: 18562315
  • ・Yoshioka M, Konno H, Takahashi T, Tanaka H, Onodera H, Tateyama M, and Itoyama Y.
    Refractory CIDP with massive loss of anterior horn cells: a clinico-pathological case report. Eur. J. Neurol. 15, 172-173.2008
  • ・Shimizu Y, Yokoyama K, Misu T, Takahashi T, Fujihara K, Kikuchi S, Itoyama Y, and Iwata M.
    Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis. Journal of Neurology, 255:305-307.2008.PMID: 18004636
  • ・Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Takata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-ura K, Sato T, Sasaki K, Nakamura Y, Yamada M, Mizusawa H, and Itoyama Y.
    Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution J Neurol. 2007 Nov;254(11):1509-17. Epub 2007 Nov 2.
  • ・Ishigaki A, Aoki M, Nagai M, Warita H, Kato S, Kato M, Nakamura T, Funakoshi H, and Itoyama Y.
    Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model J Neuropathol Exp Neurol. 2007 Nov;66(11):1037-44.
  • ・Lee TH, Yang JT, Ko YS, Kato H, Itoyama Y , and Kogure K.
    Influence of ischemic preconditioning on levels of nerve growth factor, brain-derived neurotrophic factor and their high-affinity receptors in hippocampus following forebrain ischemia. Brain Research, 1187:1-11.2008.PMID: 18036511
  • ・Nakashima I, Fujinoki M, Fujihara K, Kawamura T, Nishimura T, Nakamura M , and Itoyama Y.
    Alteration of cystatin C in the cerebrospinal fluid of multiple sclerosis. Ann Neurol 62:197-200; discussion 205.2007.PMID: 16958112
  • ・Jin K, Nakasato N, Shamoto H, Kanno A, Itoyama Y, and Tominaga T.
    Neuromagnetic localization of spike sources in perilesional, contralateral mirror, and ipsilateral remote areas in patients with cavernoma. Epilepsia. 2007 Nov;48(11):2160-6. Epub 2007 Jul 30.
  • ・Watanabe S, Misu T, Miyazawa I, Nakashima I, Shiga Y, Fujihara K , and Itoyama Y.
    Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysis. Mult Scler 13:968-974.2007.PMID: 17623727
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